Biochemical events in the activation and attenuation of the heat shock transcriptional response

Sanjeev H. Satyal, Richard I Morimoto*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The expression of heat shock proteins in response to cellular stress is mediated by a family of heat shock transcription factors (HSFs). The transcriptional activity of these HSFs is regulated by multiple redundant regulatory mechanisms which ensure the fine tuned expression of heat shock genes. These mechanisms include cis-regulatory domains and trans-acting proteins which modulate HSF activity and control the heat shock response. Heat shock gene expression is also regulated by selective use of various HSFs under distinct developmental and growth conditions.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalJournal of Biosciences
Volume23
Issue number4
DOIs
StatePublished - Jan 1 1998

Keywords

  • HSF1
  • HSF2
  • HSF3
  • Heat shock factors
  • Transcriptional activity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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