Biochemistry and physiology of the leukotrienes

Neil C. Barnes, Lewis J Smith*

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Scopus citations


Based on the studies that have used human subjects and materials, and a much larger body of data from animal and in vitro experiments, one can conclude that the LTs are potent bronchoconstrictors in normal and asthmatic subjects. A major part of their action is mediated directly via the cysLT-1 receptor on airway smooth muscle. There is also evidence for an effect on airway hyperresponsiveness probably via eosinophil recruitment and activation, airway edema, and possibly airway nerves. Taken together, these studies support a key role for the leukotrienes in asthma. However, additional studies are needed to further define their effects on the airway inflammatory response.

Original languageEnglish (US)
Pages (from-to)27-42
Number of pages16
JournalClinical Reviews in Allergy and Immunology
Issue number1-2
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Immunology and Allergy

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