Abstract
By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5360-5368 |
| Number of pages | 9 |
| Journal | Small |
| Volume | 11 |
| Issue number | 40 |
| DOIs | |
| State | Published - Oct 1 2015 |
Keywords
- DNA-brush block copolymers
- cellular uptake
- gene regulation
- micelles
- spherical nucleic acids
ASJC Scopus subject areas
- Biotechnology
- Biomaterials
- Chemistry(all)
- Materials Science(all)
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Cite this
Zhang, C., Hao, L., Calabrese, C. M., Zhou, Y., Choi, C. H. J., Xing, H., & Mirkin, C. A. (2015). Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation. Small, 11(40), 5360-5368. https://doi.org/10.1002/smll.201501573