Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation

Chuan Zhang, Liangliang Hao, Colin M. Calabrese, Yu Zhou, Chung Hang J. Choi, Hang Xing, Chad A Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.

Original languageEnglish (US)
Pages (from-to)5360-5368
Number of pages9
JournalSmall
Volume11
Issue number40
DOIs
StatePublished - Oct 1 2015

Keywords

  • DNA-brush block copolymers
  • cellular uptake
  • gene regulation
  • micelles
  • spherical nucleic acids

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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