@article{6fbc5e71007b41e8b526523616d95ce0,
title = "Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation",
abstract = "By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.",
keywords = "DNA-brush block copolymers, cellular uptake, gene regulation, micelles, spherical nucleic acids",
author = "Chuan Zhang and Liangliang Hao and Calabrese, {Colin M.} and Yu Zhou and Choi, {Chung Hang J.} and Hang Xing and Mirkin, {Chad A.}",
note = "Funding Information: C.Z., L.H., and C.M.C, contributed equally to this work. C.A.M. acknowledges support from the Center for Cancer Nanotechnology Excellence (CCNE) initiative of National Institutes of Health (NIH) Awards U54 CA119341 and U54 CA151880, Dixon Translational Research Grants Initiative, and the Defense Advanced Research Planning Agency Award N66001‐11‐1‐4189. L.H. was a Howard Hughes Medical Institute International Student Research Fellow. C.H.J.C. acknowledges a postdoctoral research fellowship from the Croucher Foundation. The electron microscopy work was performed at the Biological Imaging Facility (BIF) and the Electron Probe Instrumentation Center (EPIC) at Northwestern University. The authors also thank Dr. Natalia Chernyak for providing the azide‐terminated oligo(ethylene oxide) initiator. Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2015",
month = oct,
day = "1",
doi = "10.1002/smll.201501573",
language = "English (US)",
volume = "11",
pages = "5360--5368",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "40",
}