Bioelectric correlates of kanamycin intoxication

Peter Dallos*, Chagn Yang Wang

*Corresponding author for this work

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Young guinea pigs were given a series of subcutaneous injections of kanamycin (400 mg/kg body weight for 8-14 days) and after at least a two-week waiting period various electrical responses from the cochlea were measured. After the experiments the cochlea was perfused with osmic acid, surface preparations were used to obtain sensory (hair) cell counts, and cochleograms were prepared. In this report the relationship between the various electrical in dices of cochlear function (cochlear microphonic: CM. summating potential: SP, and whole nerve action potential: AP) and the degree and configuration of sensory cell damage is discussed. The electrode potentials were obtained with the differential electrode technique and localized CM and SP responses were collected from the first and often the third cochlear turns. Both the differential (DIF) and the average (AVE) SP components were studied. The results reveral that the CM production of inner hair cells alone is about 30-40 dB below that of the outer hair cells, and there is a 90° phase difference between the CM outputs of the two groups. The low intensity segment of the AP input-output function is missing in these cases, while they achieve near normal magnitude at high intensities. The inner hair cells apparently do not produce a positive DIF SP component

Original languageEnglish (US)
Pages (from-to)277-289
Number of pages13
JournalInternational Journal of Audiology
Volume13
Issue number4
DOIs
StatePublished - Jan 1 1974

Keywords

  • Action potential
  • Cochlear microphonic
  • Cochlear physiology
  • Inner and outer sensory cell function
  • Kanamycin intoxication
  • Summating potential

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Speech and Hearing

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