Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction

Dong Hyun Kim, Elena A. Rozhkova, Ilya V. Ulasov, Samuel D. Bader, Tijana Rajh, MacIej S. Lesniak, Valentyn Novosad

Research output: Contribution to journalArticle

326 Scopus citations

Abstract

Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental works so far have used superparamagnetic materials. This report describes a first approach based on interfacing cells with lithographically defined microdiscs that possess a spin-vortex ground state. When an alternating magnetic field is applied the microdisc vortices shift, creating an oscillation, which transmits a mechanical force to the cell. Because reduced sensitivity of cancer cells toward apoptosis leads to inappropriate cell survival and malignant progression, selective induction of apoptosis is of great importance for the anticancer therapeutic strategies. We show that the spin-vortex-mediated stimulus creates two dramatic effects: compromised integrity of the cellular membrane, and initiation of programmed cell death. A low-frequency field of a few tens of hertz applied for only ten minutes was sufficient to achieve ̃90% cancer-cell destruction in vitro.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalNature materials
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction'. Together they form a unique fingerprint.

  • Cite this