Bioinductive Scaffolds—Powerhouses of Skeletal Muscle Tissue Engineering

Hari Iyer, Robert D. Galiano*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Skeletal muscle tissue engineering is a field of vital importance to many sufferers of volumetric muscle loss (VML) and other muscular pathologies. Bioinductive scaffolds can host cells and modulate their behaviour and thus serve as a platform for muscle tissue growth. Recent Findings: Scaffolds for skeletal muscle engineering can be composed of synthetic polymers, naturally derived polymers, decellularized extracellular matrix (ECM) or any combination of these. They lead to active tissue regeneration by modulating the initial inflammatory response, recruiting progenitor cells and determining cell phenotype. Their breakdown allows cellular migration while releasing stored stimulatory compounds. Summary: Understanding the effects and advantages of the different biomaterial options might facilitate the design of novel scaffolds that support muscular regeneration, thereby restoring function and appearance to ailing patients. This review aims to present the latest advances in scaffold-based skeletal muscle tissue regeneration.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalCurrent Pathobiology Reports
Issue number3
StatePublished - Sep 1 2017


  • Biocompatible materials
  • Extracellular matrix (ECM)
  • Mesh
  • Polymers
  • Regenerative medicine
  • Skeletal muscle
  • Tissue regeneration
  • Volumetric muscle loss (VML)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology
  • Cancer Research


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