TY - JOUR
T1 - Bioinspired Chemoenzymatic Route to Artificial Melanin for Hair Pigmentation
AU - Battistella, Claudia
AU - McCallum, Naneki C.
AU - Vanthournout, Bram
AU - Forman, Christopher J.
AU - Ni, Qing Zhe
AU - La Clair, James J.
AU - Burkart, Michael D.
AU - Shawkey, Matthew D.
AU - Gianneschi, Nathan C.
N1 - Funding Information:
The authors acknowledge support from a MURI and supplemental grant from the Air Force Office of Scientific Research (FA9550-18-1-0142 and FA9550-18-1-0477). M.D.S. acknowledges support from FWO grant G007117N.
Funding Information:
This work made use of the Northwestern University Mouse Histology and Phenotyping Laboratory (NCI P30-CA060553 awarded to the Robert H Lurie Comprehensive Cancer Center) and the BioCryo facility of Northwestern University’s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); and the State of Illinois, through the IIN. It also made use of the Biological Imaging Facility (BIF) at Northwestern University.
PY - 2020/11/10
Y1 - 2020/11/10
N2 - Recent reports suggest that next-generation hair dyes might take inspiration from the natural pigment melanin. In humans, melanin imparts color to hair and skin and acts as a natural sunscreen and radical scavenger, thereby protecting lipids and proteins from damage. The most commonly employed synthetic mimic of melanin is polydopamine, and its successful deposition on human hair was recently reported. Herein, we describe an enzymatic approach to synthetic melanin for dyeing human hair in a process that closely mimics part of natural melanogenesis. This chemoenzymatic method avoids the addition of a base and enables the implementation of several monomers beyond dopamine, including tyrosine, tyramine, and their derivatives. Critically, the enzyme provides a milder process for producing coated hair fibers than conventional chemical hair dyeing methods. In addition to providing natural coloration, these coatings have the potential to act as protective sunscreens that prevent photodamage of the inner hair fibers during exposure to sunlight. The protocols developed herein represent a mild and efficient route to nature-inspired multifunctional coatings. Such materials are promising candidates for artificial hair pigmentation and, more generally, could find extensive application as functional fiber coatings.
AB - Recent reports suggest that next-generation hair dyes might take inspiration from the natural pigment melanin. In humans, melanin imparts color to hair and skin and acts as a natural sunscreen and radical scavenger, thereby protecting lipids and proteins from damage. The most commonly employed synthetic mimic of melanin is polydopamine, and its successful deposition on human hair was recently reported. Herein, we describe an enzymatic approach to synthetic melanin for dyeing human hair in a process that closely mimics part of natural melanogenesis. This chemoenzymatic method avoids the addition of a base and enables the implementation of several monomers beyond dopamine, including tyrosine, tyramine, and their derivatives. Critically, the enzyme provides a milder process for producing coated hair fibers than conventional chemical hair dyeing methods. In addition to providing natural coloration, these coatings have the potential to act as protective sunscreens that prevent photodamage of the inner hair fibers during exposure to sunlight. The protocols developed herein represent a mild and efficient route to nature-inspired multifunctional coatings. Such materials are promising candidates for artificial hair pigmentation and, more generally, could find extensive application as functional fiber coatings.
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U2 - 10.1021/acs.chemmater.0c02790
DO - 10.1021/acs.chemmater.0c02790
M3 - Article
AN - SCOPUS:85095762349
VL - 32
SP - 9201
EP - 9210
JO - Chemistry of Materials
JF - Chemistry of Materials
SN - 0897-4756
IS - 21
ER -