Biologic Agents for the Treatment of Hypereosinophilic Syndromes

Fei Li Kuang, Amy D. Klion*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Hypereosinophilic syndromes (HES) are a heterogeneous group of rare disorders defined by the presence of marked peripheral or tissue eosinophilia resulting in end-organ damage. Although conventional therapies, including glucocorticoids, hydroxyurea, and IFN-α, are initially effective in reducing eosinophilia and symptoms in a majority of patients with platelet-derived growth factor mutation-negative HES, the development of resistance and treatment-related toxicity are common. In contrast, targeted therapy with the tyrosine kinase inhibitor, imatinib, is well tolerated but effective only in the subset of patients with HES with a primary myeloid disorder. Eosinophil-targeted biotherapeutics offer the potential of improved efficacy with few, if any, adverse effects. The aims of this review are to provide an overview of current approaches to the use of conventional HES therapies and a discussion of existing biotherapeutics that target eosinophils and their potential use in the treatment of HES. With the continuing expansion of eosinophil-targeted biotherapeutics, the future for patients with eosinophilic disorders is promising.

Original languageEnglish (US)
Pages (from-to)1502-1509
Number of pages8
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume5
Issue number6
DOIs
StatePublished - Nov 2017
Externally publishedYes

Keywords

  • Hypereosinophilic syndrome
  • IL-5
  • Monoclonal antibody

ASJC Scopus subject areas

  • Immunology and Allergy

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