Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy

Sang Min Lee, Richard W. Ahn, Feng Chen, Angela J. Fought, Thomas V. Ohalloran, Vincent L. Cryns, Sonbinh T. Nguyen

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

A series of doxorubicin-loaded polymer-caged nanobins (PCNDXR) were evaluated in vivo in a murine MDA-MB-231 xenograft model of triple-negative breast cancer. The cross-linked polymer cage in PCNDXR offers protection for the drug payload while serving as a pH-responsive trigger that enhances drug release in the acidic environments commonly seen in solid tumors and endosomes. Varying the degree of cross-linking in the polymer cage allows the surface potential of PCNDXR, and thus the in vivo circulation lifetime of the nanocarriers, to be tuned in a facile fashion. Given these design advantages, the present study provides the first in vivo evidence that PCNDXR can effectively inhibit tumor growth in a murine model of breast cancer. Importantly, PCNDXR was well-tolerated by mice, and drug encapsulation attenuated the toxicity of free doxorubicin. Taken together, this study demonstrates the potential utility of the PCN platform in cancer therapy.

Original languageEnglish (US)
Pages (from-to)4971-4978
Number of pages8
JournalACS nano
Volume4
Issue number9
DOIs
StatePublished - Sep 28 2010

Keywords

  • breast cancer
  • in vivo drug delivery
  • liposome
  • pH-responsive release
  • polymers

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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