Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants

Chi Hwan Lee, Hojun Kim, Daniel V. Harburg, Gayoung Park, Yinji Ma, Taisong Pan, Jae Soon Kim, Na Yeon Lee, Bong Hoon Kim, Kyung In Jang, Seung Kyun Kang, Yonggang Huang, Jeongmin Kim, Kyung Mi Lee, Cecilia Leal*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.

Original languageEnglish (US)
Article numbere227
JournalNPG Asia Materials
Volume7
Issue number11
DOIs
StatePublished - Nov 13 2015

Fingerprint

Drug Delivery
Joule heating
Implant
Hormones
Membrane Lipids
Lipids
Drug delivery
Biocompatibility
lipids
delivery
Drugs
drugs
Membrane
Electronics
membranes
electronics
Pharmaceutical Preparations
Osteoporosis
Joule Heating
osteoporosis

ASJC Scopus subject areas

  • Modeling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Lee, Chi Hwan ; Kim, Hojun ; Harburg, Daniel V. ; Park, Gayoung ; Ma, Yinji ; Pan, Taisong ; Kim, Jae Soon ; Lee, Na Yeon ; Kim, Bong Hoon ; Jang, Kyung In ; Kang, Seung Kyun ; Huang, Yonggang ; Kim, Jeongmin ; Lee, Kyung Mi ; Leal, Cecilia ; Rogers, John A. / Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants. In: NPG Asia Materials. 2015 ; Vol. 7, No. 11.
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abstract = "On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.",
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Lee, CH, Kim, H, Harburg, DV, Park, G, Ma, Y, Pan, T, Kim, JS, Lee, NY, Kim, BH, Jang, KI, Kang, SK, Huang, Y, Kim, J, Lee, KM, Leal, C & Rogers, JA 2015, 'Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants', NPG Asia Materials, vol. 7, no. 11, e227. https://doi.org/10.1038/am.2015.114

Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants. / Lee, Chi Hwan; Kim, Hojun; Harburg, Daniel V.; Park, Gayoung; Ma, Yinji; Pan, Taisong; Kim, Jae Soon; Lee, Na Yeon; Kim, Bong Hoon; Jang, Kyung In; Kang, Seung Kyun; Huang, Yonggang; Kim, Jeongmin; Lee, Kyung Mi; Leal, Cecilia; Rogers, John A.

In: NPG Asia Materials, Vol. 7, No. 11, e227, 13.11.2015.

Research output: Contribution to journalArticle

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AU - Lee, Chi Hwan

AU - Kim, Hojun

AU - Harburg, Daniel V.

AU - Park, Gayoung

AU - Ma, Yinji

AU - Pan, Taisong

AU - Kim, Jae Soon

AU - Lee, Na Yeon

AU - Kim, Bong Hoon

AU - Jang, Kyung In

AU - Kang, Seung Kyun

AU - Huang, Yonggang

AU - Kim, Jeongmin

AU - Lee, Kyung Mi

AU - Leal, Cecilia

AU - Rogers, John A.

PY - 2015/11/13

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AB - On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.

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