Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants

Chi Hwan Lee, Hojun Kim, Daniel V. Harburg, Gayoung Park, Yinji Ma, Taisong Pan, Jae Soon Kim, Na Yeon Lee, Bong Hoon Kim, Kyung In Jang, Seung Kyun Kang, Yonggang Huang, Jeongmin Kim, Kyung Mi Lee, Cecilia Leal*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.

Original languageEnglish (US)
Article numbere227
JournalNPG Asia Materials
Volume7
Issue number11
DOIs
StatePublished - Nov 13 2015

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ASJC Scopus subject areas

  • Modeling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Lee, C. H., Kim, H., Harburg, D. V., Park, G., Ma, Y., Pan, T., Kim, J. S., Lee, N. Y., Kim, B. H., Jang, K. I., Kang, S. K., Huang, Y., Kim, J., Lee, K. M., Leal, C., & Rogers, J. A. (2015). Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants. NPG Asia Materials, 7(11), [e227]. https://doi.org/10.1038/am.2015.114