Biological Robustness and the Role of MicroRNAs. A Network Perspective

Nicolás Peláez*, Richard W Carthew

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Scopus citations

Abstract

Over the past decade, microRNA molecules have emerged as critical regulators in the expression and function of animal genomes. This review discusses the relationship between microRNA-mediated regulation and the robustness of biochemical networks that contain microRNAs. Most biochemical networks are robust; they are relatively insensitive to the precise values of reaction constants and concentrations of molecules acting within the network. MicroRNAs involved in network robustness may appear to be nonessential under favourable uniform conditions used in conventional laboratory experiments. However, the function of these molecules can be revealed under environmental and genetic perturbations. Recent advances have revealed unexpected features of microRNA organization in networks that help explain their promotion of robustness.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc
Pages237-255
Number of pages19
DOIs
StatePublished - Jan 1 2012

Publication series

NameCurrent Topics in Developmental Biology
Volume99
ISSN (Print)0070-2153

Keywords

  • Gene regulation
  • MicroRNA
  • Networks
  • Robustness
  • Systems biology

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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  • Cite this

    Peláez, N., & Carthew, R. W. (2012). Biological Robustness and the Role of MicroRNAs. A Network Perspective. In Current Topics in Developmental Biology (pp. 237-255). (Current Topics in Developmental Biology; Vol. 99). Academic Press Inc. https://doi.org/10.1016/B978-0-12-387038-4.00009-4