Biological Timekeeping

Martha U. Gillette; Sabra M. Abbott

doi:10.1016/j.jsmc.2009.01.005

Biological Timekeeping

Martha U. Gillette^*, Sabra M. Abbott

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.

Original language	English (US)
Pages (from-to)	99-110
Number of pages	12
Journal	Sleep Medicine Clinics
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jsmc.2009.01.005
State	Published - Jun 2009

Funding

This work was supported by the following past and present grants from the National Institutes of Health: HL08670, HL67007, NS22155, and NS35859 (MUG), and F30 NS047802, and GM07143 (SMA).

Keywords

Acetylcholine
Advanced Sleep Phase Syndrome
Biological rhythms
Circadian
Glutamate
Melatonin
Sleep
Suprachiasmatic nucleus

ASJC Scopus subject areas

Clinical Neurology
Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Clinical Psychology

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10.1016/j.jsmc.2009.01.005

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title = "Biological Timekeeping",

abstract = "This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.",

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year = "2009",

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T1 - Biological Timekeeping

AU - Gillette, Martha U.

AU - Abbott, Sabra M.

PY - 2009/6

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AB - This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.

KW - Acetylcholine

KW - Advanced Sleep Phase Syndrome

KW - Biological rhythms

KW - Circadian

KW - Glutamate

KW - Melatonin

KW - Sleep

KW - Suprachiasmatic nucleus

UR - https://www.scopus.com/pages/publications/66449090938

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DO - 10.1016/j.jsmc.2009.01.005

M3 - Review article

C2 - 21052483

AN - SCOPUS:66449090938

SN - 1556-407X

VL - 4

SP - 99

EP - 110

JO - Sleep Medicine Clinics

JF - Sleep Medicine Clinics

IS - 2

ER -

Biological Timekeeping

Abstract

Funding

Keywords

ASJC Scopus subject areas

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