Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

David K. Ornstein; Deborah S. Smith; Ganesh S. Rao; Joseph W. Basler; Timothy L. Ratliff; William J. Catalona

doi:10.1016/S0022-5347(01)64708-6

Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

David K. Ornstein^*, Deborah S. Smith, Ganesh S. Rao, Joseph W. Basler, Timothy L. Ratliff, William J. Catalona

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R² less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

Original language	English (US)
Pages (from-to)	2179-2182
Number of pages	4
Journal	Journal of Urology
Volume	157
Issue number	6
DOIs	https://doi.org/10.1016/S0022-5347(01)64708-6
State	Published - Jun 1997

Keywords

ejaculation
prostate
prostate-specific antigen
prostatic neoplasms

ASJC Scopus subject areas

Urology

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10.1016/S0022-5347(01)64708-6

Cite this

@article{79fc0520ec4e44fb9f772df6f06634b1,

title = "Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers",

abstract = "Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.",

keywords = "ejaculation, prostate, prostate-specific antigen, prostatic neoplasms",

author = "Ornstein, {David K.} and Smith, {Deborah S.} and Rao, {Ganesh S.} and Basler, {Joseph W.} and Ratliff, {Timothy L.} and Catalona, {William J.}",

note = "Funding Information: Supported by a grant from Hybritech Inc., San Diego, California. ",

year = "1997",

month = jun,

doi = "10.1016/S0022-5347(01)64708-6",

language = "English (US)",

volume = "157",

pages = "2179--2182",

journal = "Journal of Urology",

issn = "0022-5347",

publisher = "Wolters Kluwer Health",

number = "6",

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TY - JOUR

T1 - Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

AU - Ornstein, David K.

AU - Smith, Deborah S.

AU - Rao, Ganesh S.

AU - Basler, Joseph W.

AU - Ratliff, Timothy L.

AU - Catalona, William J.

N1 - Funding Information: Supported by a grant from Hybritech Inc., San Diego, California.

PY - 1997/6

Y1 - 1997/6

N2 - Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

AB - Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older. Materials and Methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart. Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes). Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

KW - ejaculation

KW - prostate

KW - prostate-specific antigen

KW - prostatic neoplasms

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AN - SCOPUS:0030909789

SN - 0022-5347

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JO - Journal of Urology

JF - Journal of Urology

IS - 6

ER -

Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

Abstract

Keywords

ASJC Scopus subject areas

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