TY - JOUR
T1 - Biomarkers and Therapeutic Targets in Inflammatory Breast Cancer (IBC)
AU - Avery, Tiffany
AU - Cristofanilli, Massimo
PY - 2014/11/25
Y1 - 2014/11/25
N2 - Inflammatory breast cancer (IBC) is the most aggressive type of breast cancer with survival rates far lower than other types of breast cancer. Patterns of development, invasion, and presentation are unique to IBC compared with other breast cancers. However, therapies targeted specifically to the treatment of IBC are lacking. Specific therapies, which address the unique features of IBC, are needed to improve prognosis for this type of breast cancer. The first step in developing improved treatments is to identify biomarkers and genes, which are preferentially expressed in IBC and to develop therapies targeted to these markers. In this paper, we discuss advances made in the studies of biomarkers and gene expression in IBC over the last 5 years. Some of the markers have proven to be prognostic or predictive of response to therapy. In some cases, therapies targeted for biomarkers are already used in the treatment of cancer and could be evaluated in IBC patients.
AB - Inflammatory breast cancer (IBC) is the most aggressive type of breast cancer with survival rates far lower than other types of breast cancer. Patterns of development, invasion, and presentation are unique to IBC compared with other breast cancers. However, therapies targeted specifically to the treatment of IBC are lacking. Specific therapies, which address the unique features of IBC, are needed to improve prognosis for this type of breast cancer. The first step in developing improved treatments is to identify biomarkers and genes, which are preferentially expressed in IBC and to develop therapies targeted to these markers. In this paper, we discuss advances made in the studies of biomarkers and gene expression in IBC over the last 5 years. Some of the markers have proven to be prognostic or predictive of response to therapy. In some cases, therapies targeted for biomarkers are already used in the treatment of cancer and could be evaluated in IBC patients.
KW - Biomarkers
KW - Gene expression
KW - Inflammatory breast cancer
KW - Targeted therapy
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U2 - 10.1007/s12609-014-0166-8
DO - 10.1007/s12609-014-0166-8
M3 - Review article
AN - SCOPUS:84911981359
VL - 6
SP - 245
EP - 250
JO - Current Breast Cancer Reports
JF - Current Breast Cancer Reports
SN - 1943-4588
IS - 4
ER -