Biomarkers in acute respiratory distress syndrome: From pathobiology to improving patient care

James M. Walter*, Jennifer Wilson, Lorraine B. Ware

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by alveolar flooding with protein-rich pulmonary edema fluid. Despite an improved understanding of ARDS pathogenesis, our ability to predict the development of ARDS and risk-stratify patients with the disease remains limited. Biomarkers may help identify patients at highest risk of developing ARDS, assess response to therapy, predict outcome, and optimize enrollment in clinical trials. This review begins with a general description of biomarker use in clinical medicine. We then review evidence that supports the value of various ARDS biomarkers organized by the cellular injury processes central to ARDS development: endothelial injury, epithelial injury, disordered inflammation and coagulation, fibrosis, and apoptosis. Finally, we summarize the growing contributions of genomic and proteomic research and suggest ways in which the field may evolve in the coming years.

Original languageEnglish (US)
Pages (from-to)573-586
Number of pages14
JournalExpert Review of Respiratory Medicine
Volume8
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • acute lung injury
  • acute respiratory distress syndrome
  • biomarkers
  • clinical predictor
  • genomics
  • proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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