Biomarkers of aging and lung function in the normative aging study

Cuicui Wang; Allan Just; Jonathan Heiss; Brent A. Coull; Lifang Hou; Yinan Zheng; David Sparrow; Pantel S. Vokonas; Andrea Baccarelli; Joel Schwartz

doi:10.18632/aging.103363

Biomarkers of aging and lung function in the normative aging study

Cuicui Wang^*, Allan Just, Jonathan Heiss, Brent A. Coull, Lifang Hou, Yinan Zheng, David Sparrow, Pantel S. Vokonas, Andrea Baccarelli, Joel Schwartz

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV₁/FVC), FEV₁, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95% confidence interval (CI), 5.11 to 22.16] decline in FEV₁; a 0.2 increase in Zhang's DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly.

Original language	English (US)
Pages (from-to)	11942-11966
Number of pages	25
Journal	Aging
Volume	12
Issue number	12
DOIs	https://doi.org/10.18632/aging.103363
State	Published - Jun 30 2020

Funding

This work was supported by the National Institute of Environmental Health Sciences (grants ES000002, R01ES015172, 5R01ES015172-09, 5R01ES027747-02, P30ES009089, R01ES021733, R01ES025225). The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Information Center in Boston, MA.

Keywords

Biological clock
DNA methylation
Pulmonary health

ASJC Scopus subject areas

Aging
Cell Biology

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10.18632/aging.103363

Cite this

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title = "Biomarkers of aging and lung function in the normative aging study",

abstract = "Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV1/FVC), FEV1, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95\% confidence interval (CI), 5.11 to 22.16] decline in FEV1; a 0.2 increase in Zhang's DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly.",

keywords = "Biological clock, DNA methylation, Pulmonary health",

author = "Cuicui Wang and Allan Just and Jonathan Heiss and Coull, \{Brent A.\} and Lifang Hou and Yinan Zheng and David Sparrow and Vokonas, \{Pantel S.\} and Andrea Baccarelli and Joel Schwartz",

note = "Funding Information: This work was supported by the National Institute of Environmental Health Sciences (grants ES000002, R01ES015172, 5R01ES015172-09, 5R01ES027747-02, P30ES009089, R01ES021733, R01ES025225). The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Information Center in Boston, MA. Publisher Copyright: {\textcopyright} Wang et al.",

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doi = "10.18632/aging.103363",

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AU - Wang, Cuicui

AU - Just, Allan

AU - Heiss, Jonathan

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AU - Zheng, Yinan

AU - Sparrow, David

AU - Vokonas, Pantel S.

AU - Baccarelli, Andrea

AU - Schwartz, Joel

N1 - Funding Information: This work was supported by the National Institute of Environmental Health Sciences (grants ES000002, R01ES015172, 5R01ES015172-09, 5R01ES027747-02, P30ES009089, R01ES021733, R01ES025225). The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Information Center in Boston, MA. Publisher Copyright: © Wang et al.

PY - 2020/6/30

Y1 - 2020/6/30

N2 - Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV1/FVC), FEV1, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95% confidence interval (CI), 5.11 to 22.16] decline in FEV1; a 0.2 increase in Zhang's DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly.

AB - Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV1/FVC), FEV1, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95% confidence interval (CI), 5.11 to 22.16] decline in FEV1; a 0.2 increase in Zhang's DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly.

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KW - DNA methylation

KW - Pulmonary health

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Biomarkers of aging and lung function in the normative aging study

Abstract

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Keywords

ASJC Scopus subject areas

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