TY - JOUR
T1 - Biomarkers of oral inflammation in perinatally HIV-infected and perinatally HIV-exposed, uninfected youth
AU - for the Pediatric HIV/AIDS Cohort Study
AU - Moscicki, Anna Barbara
AU - Yao, Tzy Jyun
AU - Russell, Jonathan S.
AU - Farhat, Sepideh
AU - Scott, Mark
AU - Magpantay, Larry
AU - Halec, Gordana
AU - Shiboski, Caroline H.
AU - Ryder, Mark I.
AU - Yang, Ester
AU - Shearer, William
AU - Paul, Mary
AU - Cooper, Norma
AU - Harris, Lynette
AU - Kemp-Posterman, Karen
AU - Wun, Selene
AU - Purswani, Murli
AU - Baig, Mahboobullah
AU - Cintron, Anna
AU - Zeni, Jennifer
AU - Puga, Ana
AU - Navarro, Sandra
AU - Patton, Doyle
AU - Leon, Deyana
AU - Ng, Man Wai
AU - Burchett, Sandra
AU - Karthas, Nancy
AU - Kammerer, Betsy
AU - Jurado, Ray
AU - Kuttab, Johnny
AU - Vorachek, Ashlee
AU - Yogev, Ram
AU - Sanders, Margaret Ann
AU - Malee, Kathleen
AU - Hunter, Scott
AU - Badner, Victor
AU - Garreett, Ronald
AU - Wiznia, Andrew
AU - Burey, Marlene
AU - Nozyce, Molly
AU - Chialastri, Susan
AU - Chen, Janet
AU - Ivey, Latreca
AU - Bulkley, Maria Garcia
AU - Grant, Mitzie
AU - Gonzalez, Ramon
AU - Acevedo-Flores, Midnela
AU - Rios, Heida
AU - Olivera, Vivian
AU - Townsend, Janice
N1 - Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Aim: To examine oral biomarkers that have been associated with periodontal disease progression in HIV-infected adults in perinatally HIV-infected and HIV-exposed but uninfected youth. Material and Methods: This was a cross-sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. Results: For perinatal HIV youth (n = 129), the markers consistently elevated (p <.05) in sites with GI ≥2 and in sites with BOP were interleukin-1β, 6 and 13, macrophage inflammatory protein-1α and metalloproteinase-9. Serum tumour necrosis factor-α and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV-uninfected subjects (n = 71). Conclusions: The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV-infected youth may be at higher risk for developing significant periodontal disease, associated with tooth loss and HIV progression. More frequent dental care of this group is needed to prevent potential periodontal progression.
AB - Aim: To examine oral biomarkers that have been associated with periodontal disease progression in HIV-infected adults in perinatally HIV-infected and HIV-exposed but uninfected youth. Material and Methods: This was a cross-sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. Results: For perinatal HIV youth (n = 129), the markers consistently elevated (p <.05) in sites with GI ≥2 and in sites with BOP were interleukin-1β, 6 and 13, macrophage inflammatory protein-1α and metalloproteinase-9. Serum tumour necrosis factor-α and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV-uninfected subjects (n = 71). Conclusions: The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV-infected youth may be at higher risk for developing significant periodontal disease, associated with tooth loss and HIV progression. More frequent dental care of this group is needed to prevent potential periodontal progression.
KW - cytokines
KW - oral health
KW - perinatal HIV-infected youth
KW - periodontal inflammation
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U2 - 10.1111/jcpe.13179
DO - 10.1111/jcpe.13179
M3 - Article
C2 - 31385616
AN - SCOPUS:85071966059
SN - 0303-6979
VL - 46
SP - 1072
EP - 1082
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 11
ER -