Biomarkers of Reflux Disease

Leila Kia, John E. Pandolfino, Peter J. Kahrilas*

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Gastroesophageal reflux disease (GERD) encompasses an array of disorders unified by the reflux of gastric contents. Because there are many potential disease manifestations, esophageal and extraesophageal, there is no single biomarker of the entire disease spectrum; a set of GERD biomarkers that each quantifies specific aspects of GERD-related pathology might be needed. We review recent reports of biomarkers of GERD, specifically in relation to endoscopically negative esophageal disease and excluding conventional pH-impedance monitoring. We consider histopathologic biomarkers, baseline impedance, and serologic assays to determine that most markers are based on manifestations of impaired esophageal mucosal integrity, which is based on increased ionic and molecular permeability, and/or destruction of tight junctions. Impaired mucosal integrity quantified by baseline mucosal impedance, proteolytic fragments of junctional proteins, or histopathologic features has emerged as a promising GERD biomarker.

Original languageEnglish (US)
Pages (from-to)790-797
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

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Keywords

  • Baseline impedance
  • Biomarkers
  • GERD
  • Mucosal integrity

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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