Biomaterials for regenerative medicine

Samuel I. Stupp

doi:10.1557/mrs2005.148

Biomaterials for regenerative medicine

Samuel I. Stupp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The following article is based on a presentation given by Samuel I. Stupp of Northwestern University as part of Symposium X-Frontiers of Materials Research on April 13, 2004, at the Materials Research Society Spring Meeting in San Francisco. Materials designed at the molecular and supramolecular scales to interact with cells, biomolecules, and pharmaceuticals will have a profound impact on technologies targeting the regeneration of body parts. Materials science is a great partner to stem cell biology, genomics, and proteomics in crafting the scaffolds that will effectively regenerate tissues lost to trauma, disease, or genetic defects. The repair of humans should be minimally invasive, and thus the best scaffolds would be liquids programmed to create materials inside our bodies. In this regard, self-assembling materials will play a key role in future technologies. This article illustrates how molecules are designed to assemble into cell scaffolds for human repair and provides examples relevant to brain damage, fractures of the skeleton, spinal cord injuries leading to paralysis, and diabetes.

Original language	English (US)
Pages (from-to)	546-553
Number of pages	8
Journal	MRS Bulletin
Volume	30
Issue number	7
DOIs	https://doi.org/10.1557/mrs2005.148
State	Published - Jul 2005

Funding

Work in the Stupp laboratory on fundamentals of self-assembly is supported by the Department of Energy and the National Science Foundation. Work on matrices for regenerative medicine in the author’s laboratory and at Northwestern University’s Institute for BioNanotechnol-ogy in Medicine is supported by the National Institutes of Health (Bioengineering Research Partnership), the Juvenile Diabetes Research Foundation, the U.S. Army Telemedicine and Advanced Technology Research Center (TATRC), the Baxter Corp., and Johnson & Johnson. The author is grateful to research collaborators at Northwestern, John A. Kessler, Dixon Kauffman, William Lowe, Robert Satcher, John Lomasney, Tom Meade, Monica Olvera de la Cruz, Mark Ratner, James Hulvat, Andrew Wasserstrom, Charlie Davidson, and Nitar Beohar. The author is also grateful to Mark Seniw for help with the preparation of graphics for this article.

Keywords

Biomaterials
Cell scaffolds
Self-assembly

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Physical and Theoretical Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1557/mrs2005.148

Cite this

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abstract = "The following article is based on a presentation given by Samuel I. Stupp of Northwestern University as part of Symposium X-Frontiers of Materials Research on April 13, 2004, at the Materials Research Society Spring Meeting in San Francisco. Materials designed at the molecular and supramolecular scales to interact with cells, biomolecules, and pharmaceuticals will have a profound impact on technologies targeting the regeneration of body parts. Materials science is a great partner to stem cell biology, genomics, and proteomics in crafting the scaffolds that will effectively regenerate tissues lost to trauma, disease, or genetic defects. The repair of humans should be minimally invasive, and thus the best scaffolds would be liquids programmed to create materials inside our bodies. In this regard, self-assembling materials will play a key role in future technologies. This article illustrates how molecules are designed to assemble into cell scaffolds for human repair and provides examples relevant to brain damage, fractures of the skeleton, spinal cord injuries leading to paralysis, and diabetes.",

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Biomaterials for regenerative medicine

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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