Biomechanical evaluation of a rotator cuff defect model augmented with a bioresorbable scaffold in goats

John D. MacGillivray*, Stephen Fealy, Michael A. Terry, Jason L. Koh, Alan J. Nixon, Russell F. Warren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A bioresorbable patch used for augmentation of rotator cuff repair was evaluated to determine if it would increase strength of cuff repairs associated with tendon defects and also show histologic incorporation over time. Forty goats underwent rotator cuff repairs of the infraspinatus tendon bilaterally. Tendons were detached and a defect was created prior to repair. One side was repaired and augmented with a 4 cm2 polylactic acid patch in each animal. On the other side, the same size defect was repaired in the same manner but without the patch to serve as a control. Animals were sacrificed at 3, 6, 12, and 24 weeks. Ultimate load to failure and histology were reported. No significant difference in load to failure was found between groups. A cellular fibrous tissue occupied the patch at 6 weeks, which over time matured into a dense, homogeneous fibrous tissue with alignment of collagen between the scaffold bundles.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalJournal of Shoulder and Elbow Surgery
Volume15
Issue number5
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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