Biomechanical factors as regulators of biological responses to vascular grafts

Biomechanical forces have been implicated in the induction and progression of intimal hyperplastic thickening in vein, prosthetic; and endovascular bypass grafts. Graft implantation imposes significant alterations in shear and tensile forces. Such physical forces play an important role in modulating those cellular and molecular events that underlie regulation of vascular healing and adaptation. Characterization of such hemodynamic variables that induce perpetual medial vascular smooth muscle cell proliferation and migration will help in identification of those grafts at risk for occlusion and limited long-term patency and in design of therapeutic strategies that attenuate progressive intimal hyperplasia.