Biomechanical factors as regulators of biological responses to vascular grafts

J. E. Fortunato, S. Glagov, H. S. Bassiouny*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Biomechanical forces have been implicated in the induction and progression of intimal hyperplastic thickening in vein, prosthetic; and endovascular bypass grafts. Graft implantation imposes significant alterations in shear and tensile forces. Such physical forces play an important role in modulating those cellular and molecular events that underlie regulation of vascular healing and adaptation. Characterization of such hemodynamic variables that induce perpetual medial vascular smooth muscle cell proliferation and migration will help in identification of those grafts at risk for occlusion and limited long-term patency and in design of therapeutic strategies that attenuate progressive intimal hyperplasia.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalSeminars in Vascular Surgery
Issue number1
StatePublished - 1999

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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