Biomechanical response of skeletal muscle to eccentric contractions

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The forced lengthening of an activated skeletal muscle has been termed an eccentric contraction (EC). This review highlights the mechanically unique nature of the EC and focuses on the specific disruption of proteins within the cell known as cytoskeletal proteins. The major intermediate filament cytoskeletal protein, desmin, has been the focus of work in this area because changes to desmin occur within minutes of ECs and because desmin has been shown to play both a mechanical and biologic role in a muscle's response to EC. It is hoped that these types of studies will assist in decreasing the incidence of muscle injury in athletes and facilitating the development of new therapies to treat muscle injuries.

Original languageEnglish (US)
Pages (from-to)294-309
Number of pages16
JournalJournal of Sport and Health Science
Issue number3
StatePublished - Jul 2018


  • Cytoskeleton
  • Eccentric contraction
  • Inflammation
  • Muscle injury
  • Muscle mechanics

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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