@inproceedings{ac652693b9f44242843c9b1e4233a475,
title = "Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate",
abstract = "Millions of people worldwide face partial or total vision loss due to inherited photoreceptor degenerative diseases, which currently have no cure. Retinal prostheses have been developed to restore vision by electrically stimulating surviving retinal neurons, but have low spatial resolution and nonselectively stimulate retinal ganglion cell (RGC) axons along with somata. We propose a biomimetic solution: using the neurotransmitter glutamate to chemically stimulate RGCs to avoid the disadvantages of electrical stimulation. Our results demonstrate that glutamate stimulation has a spatial resolution comparable to current-generation electrical prostheses, can stimulate RGC somata without stimulating axons, and can produce spatially differential responses in RGC subtypes. These results highlight the benefits of a neurotransmitter-based retinal prosthesis over current-generation electrical prostheses.",
author = "Rountree, \{Corey M.\} and Samsoon Inayat and Laxman Saggere and Troy, \{John B.\}",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 ; Conference date: 26-08-2014 Through 30-08-2014",
year = "2014",
month = nov,
day = "2",
doi = "10.1109/EMBC.2014.6944153",
language = "English (US)",
series = "2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2593--2596",
booktitle = "2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014",
address = "United States",
}