Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate

Corey M. Rountree, Samsoon Inayat, Laxman Saggere, John B. Troy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Millions of people worldwide face partial or total vision loss due to inherited photoreceptor degenerative diseases, which currently have no cure. Retinal prostheses have been developed to restore vision by electrically stimulating surviving retinal neurons, but have low spatial resolution and nonselectively stimulate retinal ganglion cell (RGC) axons along with somata. We propose a biomimetic solution: using the neurotransmitter glutamate to chemically stimulate RGCs to avoid the disadvantages of electrical stimulation. Our results demonstrate that glutamate stimulation has a spatial resolution comparable to current-generation electrical prostheses, can stimulate RGC somata without stimulating axons, and can produce spatially differential responses in RGC subtypes. These results highlight the benefits of a neurotransmitter-based retinal prosthesis over current-generation electrical prostheses.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2593-2596
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - Jan 1 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Rountree, C. M., Inayat, S., Saggere, L., & Troy, J. B. (2014). Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 2593-2596). [6944153] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944153