Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate

Corey M. Rountree; Samsoon Inayat; Laxman Saggere; John B. Troy

doi:10.1109/EMBC.2014.6944153

Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate

Corey M. Rountree, Samsoon Inayat, Laxman Saggere, John B. Troy

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Millions of people worldwide face partial or total vision loss due to inherited photoreceptor degenerative diseases, which currently have no cure. Retinal prostheses have been developed to restore vision by electrically stimulating surviving retinal neurons, but have low spatial resolution and nonselectively stimulate retinal ganglion cell (RGC) axons along with somata. We propose a biomimetic solution: using the neurotransmitter glutamate to chemically stimulate RGCs to avoid the disadvantages of electrical stimulation. Our results demonstrate that glutamate stimulation has a spatial resolution comparable to current-generation electrical prostheses, can stimulate RGC somata without stimulating axons, and can produce spatially differential responses in RGC subtypes. These results highlight the benefits of a neurotransmitter-based retinal prosthesis over current-generation electrical prostheses.

Original language	English (US)
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2593-2596
Number of pages	4
ISBN (Electronic)	9781424479290
DOIs	https://doi.org/10.1109/EMBC.2014.6944153
State	Published - Jan 1 2014
Event	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014

Other

Other	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country	United States
City	Chicago
Period	8/26/14 → 8/30/14

ASJC Scopus subject areas

Health Informatics
Computer Science Applications
Biomedical Engineering
Medicine(all)

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Rountree, C. M., Inayat, S., Saggere, L., & Troy, J. B. (2014). Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 2593-2596). [6944153] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944153

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Rountree, CM, Inayat, S, Saggere, L & Troy, JB 2014, Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6944153, Institute of Electrical and Electronics Engineers Inc., pp. 2593-2596, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6944153

Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate. / Rountree, Corey M.; Inayat, Samsoon; Saggere, Laxman; Troy, John B.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 2593-2596 6944153.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Rountree CM, Inayat S, Saggere L, Troy JB. Biomimetic stimulation of rat retinal ganglion cells with the neurotransmitter glutamate. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 2593-2596. 6944153 https://doi.org/10.1109/EMBC.2014.6944153