Biomolecular Densely Grafted Brush Polymers: Oligonucleotides, Oligosaccharides and Oligopeptides

Wonmin Choi, Hao Sun, Claudia Battistella, Or Berger, Maria A. Vratsanos, Max M. Wang, Nathan C. Gianneschi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


In this Minireview, we describe synthetic polymers densely functionalized with sequence-defined biomolecular sidechains. We focus on synthetic brush polymers of oligonucleotides, oligosaccharides, and oligopeptides, prepared via graft-through polymerization from biomolecule functionalized monomers. The resulting structures are brush polymers wherein a biomolecular graft is positioned at each monomer backbone unit. We describe key synthetic milestones, identify synthetic opportunities, and highlight recent advances in the field, including biological applications.

Original languageEnglish (US)
Pages (from-to)19762-19772
Number of pages11
JournalAngewandte Chemie - International Edition
Issue number45
StatePublished - Nov 2 2020


  • brush polymers
  • graft-through polymerization
  • oligonucleotides
  • oligopeptides
  • oligosaccharides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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