Biomolecular science of liposome-nanoparticle constructs

Yan Yu, Stephen M. Anthony, Sung Chul Bae, Erik Luijten, Steve Granick*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Phospholipid-nanoparticle constructs, formed by allowing nanoparticles to adsorb to the outer leaflet of liposomes, are found to be stabilized against fusion with one another. Here, through single-particle tracking by epifluorescence microscopy, we explore their use as novel colloidal particles - flexible and hollow colloidal particles that contrast strikingly with colloids of the conventional type. At the single-liposome level, the distribution of diffusion coefficients is quantified. Biomolecular function is addressed through experiments in which we explore the access of receptor to liposome-immobilized ligand, finding that receptor binding persists over a range of nanoparticle surface coverage where liposome fusion and large-scale aggregation is prevented. This opens the door to designing newer and more flexible types of tailor-made materials with desirable functionality.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalMolecular crystals and liquid crystals
Volume507
DOIs
StatePublished - Jan 1 2009

Keywords

  • Biofunctionalization
  • Colloids
  • Diffusion
  • Liposomes
  • Nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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