Biophysics of protein-DNA interactions and chromosome organization

John F. Marko

doi:10.1016/j.physa.2014.07.045

Biophysics of protein-DNA interactions and chromosome organization

John F. Marko^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

Original language	English (US)
Pages (from-to)	126-153
Number of pages	28
Journal	Physica A: Statistical Mechanics and its Applications
Volume	418
DOIs	https://doi.org/10.1016/j.physa.2014.07.045
State	Published - Jan 15 2015

Keywords

Chromosome dynamics
Chromosome structure
DNA
DNA-protein interactions

ASJC Scopus subject areas

Condensed Matter Physics
Statistics and Probability

Access to Document

10.1016/j.physa.2014.07.045

Cite this

@article{c0d854e1d4f24b38b8a0d1b79788d957,

title = "Biophysics of protein-DNA interactions and chromosome organization",

abstract = "The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.",

keywords = "Chromosome dynamics, Chromosome structure, DNA, DNA-protein interactions",

author = "Marko, {John F.}",

note = "Funding Information: This work was supported by NSF grants MCB-1022117 , DMR-1121262 (NU-MRSEC) and DMR-1206868 , and by NIH grants U54CA143869-01 (NU-PS-OC) and R01GM105847 . Publisher Copyright: {\textcopyright} 2014 Elsevier B.V. All rights reserved.",

year = "2015",

month = jan,

day = "15",

doi = "10.1016/j.physa.2014.07.045",

language = "English (US)",

volume = "418",

pages = "126--153",

journal = "Physica A: Statistical Mechanics and its Applications",

issn = "0378-4371",

publisher = "Elsevier",

}

TY - JOUR

T1 - Biophysics of protein-DNA interactions and chromosome organization

AU - Marko, John F.

N1 - Funding Information: This work was supported by NSF grants MCB-1022117 , DMR-1121262 (NU-MRSEC) and DMR-1206868 , and by NIH grants U54CA143869-01 (NU-PS-OC) and R01GM105847 . Publisher Copyright: © 2014 Elsevier B.V. All rights reserved.

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

AB - The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

KW - Chromosome dynamics

KW - Chromosome structure

KW - DNA

KW - DNA-protein interactions

UR - http://www.scopus.com/inward/record.url?scp=84910058375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84910058375&partnerID=8YFLogxK

U2 - 10.1016/j.physa.2014.07.045

DO - 10.1016/j.physa.2014.07.045

M3 - Article

C2 - 25419039

AN - SCOPUS:84910058375

SN - 0378-4371

VL - 418

SP - 126

EP - 153

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

ER -

Biophysics of protein-DNA interactions and chromosome organization

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this