Biophysics of protein-DNA interactions and chromosome organization

John F. Marko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The function of DNA in cells depends on its interactions with protein molecules, which recognize and act on base sequence patterns along the double helix. These notes aim to introduce basic polymer physics of DNA molecules, biophysics of protein-DNA interactions and their study in single-DNA experiments, and some aspects of large-scale chromosome structure. Mechanisms for control of chromosome topology will also be discussed.

Original languageEnglish (US)
Pages (from-to)126-153
Number of pages28
JournalPhysica A: Statistical Mechanics and its Applications
StatePublished - Jan 15 2015


  • Chromosome dynamics
  • Chromosome structure
  • DNA
  • DNA-protein interactions

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistics and Probability


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