Biopsy and Erectile Functional Outcomes of Partial Prostate Ablation: A Systematic Review and Meta-analysis of Prospective Studies

Dallin Busby*, Jordan M. Rich, Ralph Grauer, Basil Kaufmann, Krunal Pandav, Akshay Sood, Ashutosh K. Tewari, Mani Menon, Hiten D. Patel, Michael A. Gorin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Objective: To provide a systematic summary of prospectively performed studies evaluating ablative therapies for the treatment of prostate cancer (PCa) that included protocol-mandated assessment of (1) residual disease by post-treatment biopsy and/or (2) erectile functional outcomes. Materials and Methods: We performed a comprehensive literature search in September 2022. Studies were evaluated according to a predefined and registered plan in PROSPERO (CRD42022302777). Only prospective trials with protocol-mandated post-treatment prostate biopsies or functional assessments were included. Targeted focal therapy was the only ablation pattern with sufficient data to perform meta-analyses (29 studies, 1079 patients). Results: At baseline, 65.0% of patients treated with targeted focal therapy harbored grade group (GG) ≥2 PCa. One year after treatment, in-field treatment failure with ≥GG1 and ≥GG2 PCa occurred in 25.7% (range 11.1%-66.7%) and 8.8% (range 0%-27.8%) of men, respectively. In patients that received whole-gland biopsies 1 year after ablation, residual ≥GG1 and ≥GG2 PCa was detected anywhere in the prostate in 43.7% (range 19.4%-71.7%) and 13.0% (range 0%-35.9%) of men. Erectile function was negatively affected by treatment, but 78.7% were potent 1 year after targeted focal therapy (7 studies, 197 patients), and the average decrease in erectile function scores was 8.8% at 1 year (21 studies, 760 patients). Conclusion: Though long-term data after targeted focal therapy are limited, oncologic and treatment failure occurred in 13% and 9% (≥GG2 at 6-12 months after treatment). Most men were able to maintain potency. This work can help benchmark new techniques and power future trials.

Original languageEnglish (US)
Pages (from-to)14-26
Number of pages13
StatePublished - Dec 2023

ASJC Scopus subject areas

  • Urology


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