Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases

Donghee Son, Jongha Lee, Dong Jun Lee, Roozbeh Ghaffari, Sumin Yun, Seok Joo Kim, Ji Eun Lee, Hye Rim Cho, Soonho Yoon, Shixuan Yang, Seunghyun Lee, Shutao Qiao, Daishun Ling, Sanghun Shin, Jun Kyul Song, Jaemin Kim, Taeho Kim, Hakyong Lee, Jonghoon Kim, Min SohNohyun Lee, Cheol Seong Hwang, Sangwook Nam, Nanshu Lu, Taeghwan Hyeon*, Seung Hong Choi, Dae Hyeong Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.

Original languageEnglish (US)
Pages (from-to)5937-5946
Number of pages10
JournalACS nano
Volume9
Issue number6
DOIs
StatePublished - Jun 23 2015

Keywords

  • bioresorbable
  • flexible electronics
  • nanomedicine
  • stent
  • transient electronics

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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    Son, D., Lee, J., Lee, D. J., Ghaffari, R., Yun, S., Kim, S. J., Lee, J. E., Cho, H. R., Yoon, S., Yang, S., Lee, S., Qiao, S., Ling, D., Shin, S., Song, J. K., Kim, J., Kim, T., Lee, H., Kim, J., ... Kim, D. H. (2015). Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases. ACS nano, 9(6), 5937-5946. https://doi.org/10.1021/acsnano.5b00651