Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Jiho Shin, Zhonghe Liu, Wubin Bai, Yonghao Liu, Ying Yan, Yeguang Xue, Irawati Kandela, Maryam Pezhouh, Matthew R. MacEwan, Yonggang Huang, Wilson Z. Ray, Weidong Zhou*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


Continuous measurements of pressure and temperature within the intracranial, intraocular, and intravascular spaces provide essential diagnostic information for the treatment of traumatic brain injury, glaucoma, and cardiovascular diseases, respectively. Optical sensors are attractive because of their inherent compatibility with magnetic resonance imaging (MRI). Existing implantable optical components use permanent, nonresorbable materials that must be surgically extracted after use. Bioresorbable alternatives, introduced here, bypass this requirement, thereby eliminating the costs and risks of surgeries. Here, millimeter-scale bioresorbable Fabry-Perot interferometers and two dimensional photonic crystal structures enable precise, continuous measurements of pressure and temperature. Combined mechanical and optical simulations reveal the fundamental sensing mechanisms. In vitro studies and histopathological evaluations quantify the measurement accuracies, operational lifetimes, and biocompatibility of these systems. In vivo demonstrations establish clinically relevant performance attributes. The materials, device designs, and fabrication approaches outlined here establish broad foundational capabilities for diverse classes of bioresorbable optical sensors.

Original languageEnglish (US)
Article numbereaaw1899
JournalScience Advances
Issue number7
StatePublished - 2019

ASJC Scopus subject areas

  • General


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