Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Wubin Bai, Jiho Shin, Ruxing Fu, Irawati Kandela, Di Lu, Xiaoyue Ni, Yoonseok Park, Zhonghe Liu, Tao Hang, Di Wu, Yonghao Liu, Chad R. Haney, Iwona Stepien, Quansan Yang, Jie Zhao, Khizar Rehan Nandoliya, Hao Zhang, Xing Sheng, Lan Yin, Keith MacRenarisAnlil Brikha, Fraser Aird, Maryam Pezhouh, Jessica Hornick, Weidong Zhou, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

Original languageEnglish (US)
Pages (from-to)644-654
Number of pages11
JournalNature Biomedical Engineering
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Optics and Photonics
Photonic devices
Equipment and Supplies
Monitoring
Recovery
Oxygenation
Pathology
Physiological Phenomena
Drug delivery
Patient rehabilitation
Neurosciences
Tissue
Imaging techniques
Appointments and Schedules
Rehabilitation
Sensors
Pharmacology
Costs and Cost Analysis
Injections
Temperature

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Bai, Wubin ; Shin, Jiho ; Fu, Ruxing ; Kandela, Irawati ; Lu, Di ; Ni, Xiaoyue ; Park, Yoonseok ; Liu, Zhonghe ; Hang, Tao ; Wu, Di ; Liu, Yonghao ; Haney, Chad R. ; Stepien, Iwona ; Yang, Quansan ; Zhao, Jie ; Nandoliya, Khizar Rehan ; Zhang, Hao ; Sheng, Xing ; Yin, Lan ; MacRenaris, Keith ; Brikha, Anlil ; Aird, Fraser ; Pezhouh, Maryam ; Hornick, Jessica ; Zhou, Weidong ; Rogers, John A. / Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. In: Nature Biomedical Engineering. 2019 ; Vol. 3, No. 8. pp. 644-654.
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abstract = "Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.",
author = "Wubin Bai and Jiho Shin and Ruxing Fu and Irawati Kandela and Di Lu and Xiaoyue Ni and Yoonseok Park and Zhonghe Liu and Tao Hang and Di Wu and Yonghao Liu and Haney, {Chad R.} and Iwona Stepien and Quansan Yang and Jie Zhao and Nandoliya, {Khizar Rehan} and Hao Zhang and Xing Sheng and Lan Yin and Keith MacRenaris and Anlil Brikha and Fraser Aird and Maryam Pezhouh and Jessica Hornick and Weidong Zhou and Rogers, {John A.}",
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Bai, W, Shin, J, Fu, R, Kandela, I, Lu, D, Ni, X, Park, Y, Liu, Z, Hang, T, Wu, D, Liu, Y, Haney, CR, Stepien, I, Yang, Q, Zhao, J, Nandoliya, KR, Zhang, H, Sheng, X, Yin, L, MacRenaris, K, Brikha, A, Aird, F, Pezhouh, M, Hornick, J, Zhou, W & Rogers, JA 2019, 'Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity', Nature Biomedical Engineering, vol. 3, no. 8, pp. 644-654. https://doi.org/10.1038/s41551-019-0435-y

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. / Bai, Wubin; Shin, Jiho; Fu, Ruxing; Kandela, Irawati; Lu, Di; Ni, Xiaoyue; Park, Yoonseok; Liu, Zhonghe; Hang, Tao; Wu, Di; Liu, Yonghao; Haney, Chad R.; Stepien, Iwona; Yang, Quansan; Zhao, Jie; Nandoliya, Khizar Rehan; Zhang, Hao; Sheng, Xing; Yin, Lan; MacRenaris, Keith; Brikha, Anlil; Aird, Fraser; Pezhouh, Maryam; Hornick, Jessica; Zhou, Weidong; Rogers, John A.

In: Nature Biomedical Engineering, Vol. 3, No. 8, 01.08.2019, p. 644-654.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

AU - Bai, Wubin

AU - Shin, Jiho

AU - Fu, Ruxing

AU - Kandela, Irawati

AU - Lu, Di

AU - Ni, Xiaoyue

AU - Park, Yoonseok

AU - Liu, Zhonghe

AU - Hang, Tao

AU - Wu, Di

AU - Liu, Yonghao

AU - Haney, Chad R.

AU - Stepien, Iwona

AU - Yang, Quansan

AU - Zhao, Jie

AU - Nandoliya, Khizar Rehan

AU - Zhang, Hao

AU - Sheng, Xing

AU - Yin, Lan

AU - MacRenaris, Keith

AU - Brikha, Anlil

AU - Aird, Fraser

AU - Pezhouh, Maryam

AU - Hornick, Jessica

AU - Zhou, Weidong

AU - Rogers, John A.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

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