Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Wubin Bai, Jiho Shin, Ruxing Fu, Irawati Kandela, Di Lu, Xiaoyue Ni, Yoonseok Park, Zhonghe Liu, Tao Hang, Di Wu, Yonghao Liu, Chad R. Haney, Iwona Stepien, Quansan Yang, Jie Zhao, Khizar Rehan Nandoliya, Hao Zhang, Xing Sheng, Lan Yin, Keith MacRenarisAnlil Brikha, Fraser Aird, Maryam Pezhouh, Jessica Hornick, Weidong Zhou, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

Original languageEnglish (US)
Pages (from-to)644-654
Number of pages11
JournalNature Biomedical Engineering
Issue number8
StatePublished - Aug 1 2019

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications


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