Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Wubin Bai; Jiho Shin; Ruxing Fu; Irawati Kandela; Di Lu; Xiaoyue Ni; Yoonseok Park; Zhonghe Liu; Tao Hang; Di Wu; Yonghao Liu; Chad R. Haney; Iwona Stepien; Quansan Yang; Jie Zhao; Khizar Rehan Nandoliya; Hao Zhang; Xing Sheng; Lan Yin; Keith MacRenaris; Anlil Brikha; Fraser Aird; Maryam Pezhouh; Jessica Hornick; Weidong Zhou; John A. Rogers

doi:10.1038/s41551-019-0435-y

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Wubin Bai, Jiho Shin, Ruxing Fu, Irawati Kandela, Di Lu, Xiaoyue Ni, Yoonseok Park, Zhonghe Liu, Tao Hang, Di Wu, Yonghao Liu, Chad R. Haney, Iwona Stepien, Quansan Yang, Jie Zhao, Khizar Rehan Nandoliya, Hao Zhang, Xing Sheng, Lan Yin, Keith MacRenarisAnlil Brikha, Fraser Aird, Maryam Pezhouh, Jessica Hornick, Weidong Zhou, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

Original language	English (US)
Pages (from-to)	644-654
Number of pages	11
Journal	Nature Biomedical Engineering
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/s41551-019-0435-y
State	Published - Aug 1 2019

Funding

W.Z. acknowledges support from the Army Research Office under grant W911NF-15-1-0035. This work utilized the Northwestern University Micro/Nano Fabrication Facility, which is partially supported by the Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205), Materials Research Science and Engineering Center (NSF DMR-1121262), State of Illinois, Northwestern University and Center for Bio-Integrated Electronics (Simpson Querrey Institute). The Center for Developmental Therapeutics is supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

Access to Document

10.1038/s41551-019-0435-y

Cite this

Bai, W., Shin, J., Fu, R., Kandela, I., Lu, D., Ni, X., Park, Y., Liu, Z., Hang, T., Wu, D., Liu, Y., Haney, C. R., Stepien, I., Yang, Q., Zhao, J., Nandoliya, K. R., Zhang, H., Sheng, X., Yin, L., ... Rogers, J. A. (2019). Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. Nature Biomedical Engineering, 3(8), 644-654. https://doi.org/10.1038/s41551-019-0435-y

@article{17df0fe01ad643699790021a8af07a15,

title = "Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity",

abstract = "Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.",

author = "Wubin Bai and Jiho Shin and Ruxing Fu and Irawati Kandela and Di Lu and Xiaoyue Ni and Yoonseok Park and Zhonghe Liu and Tao Hang and Di Wu and Yonghao Liu and Haney, {Chad R.} and Iwona Stepien and Quansan Yang and Jie Zhao and Nandoliya, {Khizar Rehan} and Hao Zhang and Xing Sheng and Lan Yin and Keith MacRenaris and Anlil Brikha and Fraser Aird and Maryam Pezhouh and Jessica Hornick and Weidong Zhou and Rogers, {John A.}",

note = "Funding Information: W.Z. acknowledges support from the Army Research Office under grant W911NF-15-1-0035. This work utilized the Northwestern University Micro/Nano Fabrication Facility, which is partially supported by the Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205), Materials Research Science and Engineering Center (NSF DMR-1121262), State of Illinois, Northwestern University and Center for Bio-Integrated Electronics (Simpson Querrey Institute). The Center for Developmental Therapeutics is supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature Limited. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = aug,

day = "1",

doi = "10.1038/s41551-019-0435-y",

language = "English (US)",

volume = "3",

pages = "644--654",

journal = "Nature Biomedical Engineering",

issn = "2157-846X",

publisher = "Nature Research",

number = "8",

}

Bai, W, Shin, J, Fu, R, Kandela, I, Lu, D, Ni, X, Park, Y, Liu, Z, Hang, T, Wu, D, Liu, Y, Haney, CR, Stepien, I, Yang, Q, Zhao, J, Nandoliya, KR, Zhang, H, Sheng, X, Yin, L, MacRenaris, K, Brikha, A, Aird, F, Pezhouh, M, Hornick, J, Zhou, W & Rogers, JA 2019, 'Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity', Nature Biomedical Engineering, vol. 3, no. 8, pp. 644-654. https://doi.org/10.1038/s41551-019-0435-y

TY - JOUR

T1 - Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

AU - Bai, Wubin

AU - Shin, Jiho

AU - Fu, Ruxing

AU - Kandela, Irawati

AU - Lu, Di

AU - Ni, Xiaoyue

AU - Park, Yoonseok

AU - Liu, Zhonghe

AU - Hang, Tao

AU - Wu, Di

AU - Liu, Yonghao

AU - Haney, Chad R.

AU - Stepien, Iwona

AU - Yang, Quansan

AU - Zhao, Jie

AU - Nandoliya, Khizar Rehan

AU - Zhang, Hao

AU - Sheng, Xing

AU - Yin, Lan

AU - MacRenaris, Keith

AU - Brikha, Anlil

AU - Aird, Fraser

AU - Pezhouh, Maryam

AU - Hornick, Jessica

AU - Zhou, Weidong

AU - Rogers, John A.

N1 - Funding Information: W.Z. acknowledges support from the Army Research Office under grant W911NF-15-1-0035. This work utilized the Northwestern University Micro/Nano Fabrication Facility, which is partially supported by the Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205), Materials Research Science and Engineering Center (NSF DMR-1121262), State of Illinois, Northwestern University and Center for Bio-Integrated Electronics (Simpson Querrey Institute). The Center for Developmental Therapeutics is supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. Publisher Copyright: © 2019, The Author(s), under exclusive licence to Springer Nature Limited. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

AB - Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

UR - http://www.scopus.com/inward/record.url?scp=85070391189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070391189&partnerID=8YFLogxK

U2 - 10.1038/s41551-019-0435-y

DO - 10.1038/s41551-019-0435-y

M3 - Article

C2 - 31391594

AN - SCOPUS:85070391189

SN - 2157-846X

VL - 3

SP - 644

EP - 654

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 8

ER -

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this