Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Jiho Shin, Ying Yan, Wubin Bai, Yeguang Xue, Paul Gamble, Limei Tian, Irawati Kandela, Chad R Haney, William Spees, Yechan Lee, Minseok Choi, Jonathan Ko, Hangyu Ryu, Jan Kai Chang, Maryam Kherad Pezhouh, Seung Kyun Kang, Sang Min Won, Ki Jun Yu, Jianing Zhao, Yoon Kyeung Lee & 5 others Matthew R. MacEwan, Sheng Kwei Song, Yonggang Huang, Wilson Z. Ray, John A Rogers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pressures in the intracranial, intraocular and intravascular spaces are clinically useful for the diagnosis and management of traumatic brain injury, glaucoma and hypertension, respectively. Conventional devices for measuring these pressures require surgical extraction after a relevant operational time frame. Bioresorbable sensors, by contrast, eliminate this requirement, thereby minimizing the risk of infection, decreasing the costs of care and reducing distress and pain for the patient. However, the operational lifetimes of bioresorbable pressure sensors available at present fall short of many clinical needs. Here, we present materials, device structures and fabrication procedures for bioresorbable pressure sensors with lifetimes exceeding those of previous reports by at least tenfold. We demonstrate measurement accuracies that compare favourably to those of the most sophisticated clinical standards for non-resorbable devices by monitoring intracranial pressures in rats for 25 days. Assessments of the biodistribution of the constituent materials, complete blood counts, blood chemistry and magnetic resonance imaging compatibility confirm the biodegradability and clinical utility of the device. Our findings establish routes for the design and fabrication of bioresorbable pressure monitors that meet requirements for clinical use.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalNature Biomedical Engineering
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pressure sensors
Silicon Dioxide
Chronic Disease
Silica
Pressure
Equipment and Supplies
Monitoring
Intracranial Pressure
Blood
Fabrication
Blood Cell Count
Biodegradability
Magnetic resonance
Glaucoma
Rats
Brain
Magnetic Resonance Imaging
Hypertension
Imaging techniques
Costs and Cost Analysis

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Shin, Jiho ; Yan, Ying ; Bai, Wubin ; Xue, Yeguang ; Gamble, Paul ; Tian, Limei ; Kandela, Irawati ; Haney, Chad R ; Spees, William ; Lee, Yechan ; Choi, Minseok ; Ko, Jonathan ; Ryu, Hangyu ; Chang, Jan Kai ; Kherad Pezhouh, Maryam ; Kang, Seung Kyun ; Won, Sang Min ; Yu, Ki Jun ; Zhao, Jianing ; Lee, Yoon Kyeung ; MacEwan, Matthew R. ; Song, Sheng Kwei ; Huang, Yonggang ; Ray, Wilson Z. ; Rogers, John A. / Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes. In: Nature Biomedical Engineering. 2019 ; Vol. 3, No. 1. pp. 37-46.
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Shin, J, Yan, Y, Bai, W, Xue, Y, Gamble, P, Tian, L, Kandela, I, Haney, CR, Spees, W, Lee, Y, Choi, M, Ko, J, Ryu, H, Chang, JK, Kherad Pezhouh, M, Kang, SK, Won, SM, Yu, KJ, Zhao, J, Lee, YK, MacEwan, MR, Song, SK, Huang, Y, Ray, WZ & Rogers, JA 2019, 'Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes' Nature Biomedical Engineering, vol. 3, no. 1, pp. 37-46. https://doi.org/10.1038/s41551-018-0300-4

Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes. / Shin, Jiho; Yan, Ying; Bai, Wubin; Xue, Yeguang; Gamble, Paul; Tian, Limei; Kandela, Irawati; Haney, Chad R; Spees, William; Lee, Yechan; Choi, Minseok; Ko, Jonathan; Ryu, Hangyu; Chang, Jan Kai; Kherad Pezhouh, Maryam; Kang, Seung Kyun; Won, Sang Min; Yu, Ki Jun; Zhao, Jianing; Lee, Yoon Kyeung; MacEwan, Matthew R.; Song, Sheng Kwei; Huang, Yonggang; Ray, Wilson Z.; Rogers, John A.

In: Nature Biomedical Engineering, Vol. 3, No. 1, 01.01.2019, p. 37-46.

Research output: Contribution to journalArticle

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AU - Shin, Jiho

AU - Yan, Ying

AU - Bai, Wubin

AU - Xue, Yeguang

AU - Gamble, Paul

AU - Tian, Limei

AU - Kandela, Irawati

AU - Haney, Chad R

AU - Spees, William

AU - Lee, Yechan

AU - Choi, Minseok

AU - Ko, Jonathan

AU - Ryu, Hangyu

AU - Chang, Jan Kai

AU - Kherad Pezhouh, Maryam

AU - Kang, Seung Kyun

AU - Won, Sang Min

AU - Yu, Ki Jun

AU - Zhao, Jianing

AU - Lee, Yoon Kyeung

AU - MacEwan, Matthew R.

AU - Song, Sheng Kwei

AU - Huang, Yonggang

AU - Ray, Wilson Z.

AU - Rogers, John A

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pressures in the intracranial, intraocular and intravascular spaces are clinically useful for the diagnosis and management of traumatic brain injury, glaucoma and hypertension, respectively. Conventional devices for measuring these pressures require surgical extraction after a relevant operational time frame. Bioresorbable sensors, by contrast, eliminate this requirement, thereby minimizing the risk of infection, decreasing the costs of care and reducing distress and pain for the patient. However, the operational lifetimes of bioresorbable pressure sensors available at present fall short of many clinical needs. Here, we present materials, device structures and fabrication procedures for bioresorbable pressure sensors with lifetimes exceeding those of previous reports by at least tenfold. We demonstrate measurement accuracies that compare favourably to those of the most sophisticated clinical standards for non-resorbable devices by monitoring intracranial pressures in rats for 25 days. Assessments of the biodistribution of the constituent materials, complete blood counts, blood chemistry and magnetic resonance imaging compatibility confirm the biodegradability and clinical utility of the device. Our findings establish routes for the design and fabrication of bioresorbable pressure monitors that meet requirements for clinical use.

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