Bioresorbable silicon electronic sensors for the brain

Seung Kyun Kang, Rory K J Murphy, Suk Won Hwang, Seung Min Lee, Daniel V. Harburg, Neil A. Krueger, Jiho Shin, Paul Gamble, Huanyu Cheng, Sooyoun Yu, Zhuangjian Liu, Jordan G. McCall, Manu Stephen, Hanze Ying, Jeonghyun Kim, Gayoung Park, R. Chad Webb, Chi Hwan Lee, Sangjin Chung, Dae Seung Wie & 10 others Amit D. Gujar, Bharat Vemulapalli, Albert H. Kim, Kyung Mi Lee, Jianjun Cheng, Younggang Huang, Sang Hoon Lee, Paul V. Braun, Wilson Z. Ray, John A. Rogers

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Many procedures in modern clinical medicine rely on the use of electronic implants in treating conditions that range from acute coronary events to traumatic injury. However, standard permanent electronic hardware acts as a nidus for infection: bacteria form biofilms along percutaneous wires, or seed haematogenously, with the potential to migrate within the body and to provoke immune-mediated pathological tissue reactions. The associated surgical retrieval procedures, meanwhile, subject patients to the distress associated with re-operation and expose them to additional complications. Here, we report materials, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction. Continuous monitoring of intracranial pressure and temperature illustrates functionality essential to the treatment of traumatic brain injury; the measurement performance of our resorbable devices compares favourably with that of non-resorbable clinical standards. In our experiments, insulated percutaneous wires connect to an externally mounted, miniaturized wireless potentiostat for data transmission. In a separate set-up, we connect a sensor to an implanted (but only partially resorbable) data-communication system, proving the principle that there is no need for any percutaneous wiring. The devices can be adapted to sense fluid flow, motion, pH or thermal characteristics, in formats that are compatible with the body's abdomen and extremities, as well as the deep brain, suggesting that the sensors might meet many needs in clinical medicine.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalNature
Volume530
Issue number7588
DOIs
StatePublished - Feb 4 2016

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Silicon
Clinical Medicine
Equipment and Supplies
Brain
Modern 1601-history
Intracranial Pressure
Biofilms
Information Systems
Abdomen
Seeds
Hydrolysis
Extremities
Hot Temperature
Communication
Bacteria
Temperature
Wounds and Injuries
Infection
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Kang, S. K., Murphy, R. K. J., Hwang, S. W., Lee, S. M., Harburg, D. V., Krueger, N. A., ... Rogers, J. A. (2016). Bioresorbable silicon electronic sensors for the brain. Nature, 530(7588), 71-76. https://doi.org/10.1038/nature16492
Kang, Seung Kyun ; Murphy, Rory K J ; Hwang, Suk Won ; Lee, Seung Min ; Harburg, Daniel V. ; Krueger, Neil A. ; Shin, Jiho ; Gamble, Paul ; Cheng, Huanyu ; Yu, Sooyoun ; Liu, Zhuangjian ; McCall, Jordan G. ; Stephen, Manu ; Ying, Hanze ; Kim, Jeonghyun ; Park, Gayoung ; Webb, R. Chad ; Lee, Chi Hwan ; Chung, Sangjin ; Wie, Dae Seung ; Gujar, Amit D. ; Vemulapalli, Bharat ; Kim, Albert H. ; Lee, Kyung Mi ; Cheng, Jianjun ; Huang, Younggang ; Lee, Sang Hoon ; Braun, Paul V. ; Ray, Wilson Z. ; Rogers, John A. / Bioresorbable silicon electronic sensors for the brain. In: Nature. 2016 ; Vol. 530, No. 7588. pp. 71-76.
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abstract = "Many procedures in modern clinical medicine rely on the use of electronic implants in treating conditions that range from acute coronary events to traumatic injury. However, standard permanent electronic hardware acts as a nidus for infection: bacteria form biofilms along percutaneous wires, or seed haematogenously, with the potential to migrate within the body and to provoke immune-mediated pathological tissue reactions. The associated surgical retrieval procedures, meanwhile, subject patients to the distress associated with re-operation and expose them to additional complications. Here, we report materials, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction. Continuous monitoring of intracranial pressure and temperature illustrates functionality essential to the treatment of traumatic brain injury; the measurement performance of our resorbable devices compares favourably with that of non-resorbable clinical standards. In our experiments, insulated percutaneous wires connect to an externally mounted, miniaturized wireless potentiostat for data transmission. In a separate set-up, we connect a sensor to an implanted (but only partially resorbable) data-communication system, proving the principle that there is no need for any percutaneous wiring. The devices can be adapted to sense fluid flow, motion, pH or thermal characteristics, in formats that are compatible with the body's abdomen and extremities, as well as the deep brain, suggesting that the sensors might meet many needs in clinical medicine.",
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Kang, SK, Murphy, RKJ, Hwang, SW, Lee, SM, Harburg, DV, Krueger, NA, Shin, J, Gamble, P, Cheng, H, Yu, S, Liu, Z, McCall, JG, Stephen, M, Ying, H, Kim, J, Park, G, Webb, RC, Lee, CH, Chung, S, Wie, DS, Gujar, AD, Vemulapalli, B, Kim, AH, Lee, KM, Cheng, J, Huang, Y, Lee, SH, Braun, PV, Ray, WZ & Rogers, JA 2016, 'Bioresorbable silicon electronic sensors for the brain', Nature, vol. 530, no. 7588, pp. 71-76. https://doi.org/10.1038/nature16492

Bioresorbable silicon electronic sensors for the brain. / Kang, Seung Kyun; Murphy, Rory K J; Hwang, Suk Won; Lee, Seung Min; Harburg, Daniel V.; Krueger, Neil A.; Shin, Jiho; Gamble, Paul; Cheng, Huanyu; Yu, Sooyoun; Liu, Zhuangjian; McCall, Jordan G.; Stephen, Manu; Ying, Hanze; Kim, Jeonghyun; Park, Gayoung; Webb, R. Chad; Lee, Chi Hwan; Chung, Sangjin; Wie, Dae Seung; Gujar, Amit D.; Vemulapalli, Bharat; Kim, Albert H.; Lee, Kyung Mi; Cheng, Jianjun; Huang, Younggang; Lee, Sang Hoon; Braun, Paul V.; Ray, Wilson Z.; Rogers, John A.

In: Nature, Vol. 530, No. 7588, 04.02.2016, p. 71-76.

Research output: Contribution to journalArticle

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AU - Kang, Seung Kyun

AU - Murphy, Rory K J

AU - Hwang, Suk Won

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AU - Krueger, Neil A.

AU - Shin, Jiho

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AU - Cheng, Huanyu

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AU - McCall, Jordan G.

AU - Stephen, Manu

AU - Ying, Hanze

AU - Kim, Jeonghyun

AU - Park, Gayoung

AU - Webb, R. Chad

AU - Lee, Chi Hwan

AU - Chung, Sangjin

AU - Wie, Dae Seung

AU - Gujar, Amit D.

AU - Vemulapalli, Bharat

AU - Kim, Albert H.

AU - Lee, Kyung Mi

AU - Cheng, Jianjun

AU - Huang, Younggang

AU - Lee, Sang Hoon

AU - Braun, Paul V.

AU - Ray, Wilson Z.

AU - Rogers, John A.

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Kang SK, Murphy RKJ, Hwang SW, Lee SM, Harburg DV, Krueger NA et al. Bioresorbable silicon electronic sensors for the brain. Nature. 2016 Feb 4;530(7588):71-76. https://doi.org/10.1038/nature16492