Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

Ki Jun Yu, Duygu Kuzum, Suk Won Hwang, Bong Hoon Kim, Halvor Juul, Nam Heon Kim, Sang Min Won, Ken Chiang, Michael Trumpis, Andrew G. Richardson, Huanyu Cheng, Hui Fang, Marissa Thompson, Hank Bink, Delia Talos, Kyung Jin Seo, Hee Nam Lee, Seung Kyun Kang, Jae Hwan Kim, Jung Yup Lee & 7 others Younggang Huang, Frances E. Jensen, Marc A. Dichter, Timothy H. Lucas, Jonathan Viventi, Brian Litt, John A. Rogers

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

Original languageEnglish (US)
Pages (from-to)782-791
Number of pages10
JournalNature materials
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

cerebral cortex
Silicon
Electronic equipment
recording
orthopedics
electrodes
Monitoring
silicon
regeneration
multiplexing
electronics
integrity
Tissue
Electrodes
reactivity
recovery
Orthopedics
disorders
costs
Multiplexing

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Yu, Ki Jun ; Kuzum, Duygu ; Hwang, Suk Won ; Kim, Bong Hoon ; Juul, Halvor ; Kim, Nam Heon ; Won, Sang Min ; Chiang, Ken ; Trumpis, Michael ; Richardson, Andrew G. ; Cheng, Huanyu ; Fang, Hui ; Thompson, Marissa ; Bink, Hank ; Talos, Delia ; Seo, Kyung Jin ; Lee, Hee Nam ; Kang, Seung Kyun ; Kim, Jae Hwan ; Lee, Jung Yup ; Huang, Younggang ; Jensen, Frances E. ; Dichter, Marc A. ; Lucas, Timothy H. ; Viventi, Jonathan ; Litt, Brian ; Rogers, John A. / Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. In: Nature materials. 2016 ; Vol. 15, No. 7. pp. 782-791.
@article{1bd73977da47499cb41520653e4627f9,
title = "Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex",
abstract = "Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.",
author = "Yu, {Ki Jun} and Duygu Kuzum and Hwang, {Suk Won} and Kim, {Bong Hoon} and Halvor Juul and Kim, {Nam Heon} and Won, {Sang Min} and Ken Chiang and Michael Trumpis and Richardson, {Andrew G.} and Huanyu Cheng and Hui Fang and Marissa Thompson and Hank Bink and Delia Talos and Seo, {Kyung Jin} and Lee, {Hee Nam} and Kang, {Seung Kyun} and Kim, {Jae Hwan} and Lee, {Jung Yup} and Younggang Huang and Jensen, {Frances E.} and Dichter, {Marc A.} and Lucas, {Timothy H.} and Jonathan Viventi and Brian Litt and Rogers, {John A.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1038/nmat4624",
language = "English (US)",
volume = "15",
pages = "782--791",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "Nature Publishing Group",
number = "7",

}

Yu, KJ, Kuzum, D, Hwang, SW, Kim, BH, Juul, H, Kim, NH, Won, SM, Chiang, K, Trumpis, M, Richardson, AG, Cheng, H, Fang, H, Thompson, M, Bink, H, Talos, D, Seo, KJ, Lee, HN, Kang, SK, Kim, JH, Lee, JY, Huang, Y, Jensen, FE, Dichter, MA, Lucas, TH, Viventi, J, Litt, B & Rogers, JA 2016, 'Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex', Nature materials, vol. 15, no. 7, pp. 782-791. https://doi.org/10.1038/nmat4624

Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. / Yu, Ki Jun; Kuzum, Duygu; Hwang, Suk Won; Kim, Bong Hoon; Juul, Halvor; Kim, Nam Heon; Won, Sang Min; Chiang, Ken; Trumpis, Michael; Richardson, Andrew G.; Cheng, Huanyu; Fang, Hui; Thompson, Marissa; Bink, Hank; Talos, Delia; Seo, Kyung Jin; Lee, Hee Nam; Kang, Seung Kyun; Kim, Jae Hwan; Lee, Jung Yup; Huang, Younggang; Jensen, Frances E.; Dichter, Marc A.; Lucas, Timothy H.; Viventi, Jonathan; Litt, Brian; Rogers, John A.

In: Nature materials, Vol. 15, No. 7, 01.07.2016, p. 782-791.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

AU - Yu, Ki Jun

AU - Kuzum, Duygu

AU - Hwang, Suk Won

AU - Kim, Bong Hoon

AU - Juul, Halvor

AU - Kim, Nam Heon

AU - Won, Sang Min

AU - Chiang, Ken

AU - Trumpis, Michael

AU - Richardson, Andrew G.

AU - Cheng, Huanyu

AU - Fang, Hui

AU - Thompson, Marissa

AU - Bink, Hank

AU - Talos, Delia

AU - Seo, Kyung Jin

AU - Lee, Hee Nam

AU - Kang, Seung Kyun

AU - Kim, Jae Hwan

AU - Lee, Jung Yup

AU - Huang, Younggang

AU - Jensen, Frances E.

AU - Dichter, Marc A.

AU - Lucas, Timothy H.

AU - Viventi, Jonathan

AU - Litt, Brian

AU - Rogers, John A.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

AB - Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

UR - http://www.scopus.com/inward/record.url?scp=84992292403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992292403&partnerID=8YFLogxK

U2 - 10.1038/nmat4624

DO - 10.1038/nmat4624

M3 - Article

VL - 15

SP - 782

EP - 791

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 7

ER -