Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex

Ki Jun Yu, Duygu Kuzum, Suk Won Hwang, Bong Hoon Kim, Halvor Juul, Nam Heon Kim, Sang Min Won, Ken Chiang, Michael Trumpis, Andrew G. Richardson, Huanyu Cheng, Hui Fang, Marissa Thompson, Hank Bink, Delia Talos, Kyung Jin Seo, Hee Nam Lee, Seung Kyun Kang, Jae Hwan Kim, Jung Yup LeeYounggang Huang, Frances E. Jensen, Marc A. Dichter, Timothy H. Lucas, Jonathan Viventi, Brian Litt*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

173 Scopus citations

Abstract

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

Original languageEnglish (US)
Pages (from-to)782-791
Number of pages10
JournalNature materials
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Yu, K. J., Kuzum, D., Hwang, S. W., Kim, B. H., Juul, H., Kim, N. H., Won, S. M., Chiang, K., Trumpis, M., Richardson, A. G., Cheng, H., Fang, H., Thompson, M., Bink, H., Talos, D., Seo, K. J., Lee, H. N., Kang, S. K., Kim, J. H., ... Rogers, J. A. (2016). Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. Nature materials, 15(7), 782-791. https://doi.org/10.1038/nmat4624