Bioresorbable stent to manage congenital heart defects in children

Jamie Wright, Annie Nguyen, Nandika D'Souza, Joseph M. Forbess, Alan Nugent, Surendranath R.Veeram Reddy, Robert Jaquiss, Tré Raymond Welch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Intravascular stents for pediatric patients that degrade without inhibiting vessel growth remain a clinical challenge. Here, poly(L-lactide) fibers (DH-BDS) at two thicknesses, 250 µm and 300 µm, were assembled into large, pediatric-sized stents (Ø10 - Ø20 mm). Fibers were characterized mechanically and thermally, then stent mechanical properties were compared to metal controls, while mass loss and degradation kinetics modeling estimated total stent degradation time. Thicker fibers displayed lower stiffness (1969 ± 44 vs 2126 ± 37 MPa) and yield stress (117 ± 12 vs 137 ± 5 MPa) than thinner counterparts, but exhibited similar fail strength (478 ± 28 vs 476 ± 16 MPa) at higher strains (47 ± 2 vs 44 ± 2%). Stents all exhibited crystallinity between 51.3 – 54.4% and fiber glass transition temperatures of 88.6 ± 0.5°C and 84.6 ± 0.5°C were well above physiological ranges. Radial strength (0.31 ± 0.01 - 0.34 ± 0.02 N/mm) in thinner stents was similar to metal stents (0.24 – 0.41 N/mm) up to Ø14 mm with no foreshortening and thicker coils granted comparable radial strength (0.32 ± 0.02 - 0.34 ± 0.02 N/mm) in stents larger than Ø14 mm. Both 10 mm (1.17 ± 0.02 % and 0.86 ± 0.1 %) and 12 mm (1.1 ± 0.03% and 0.89 ± 0.1%) stents exhibited minimal weight loss over one year. Degradation kinetics models predicted full stent degradation within 2.8 - 4.5 years depending on thickness. DH-BDS exhibiting hoop strength similar to metal stents and demonstrating minimal degradation and strength loss over the first year before completely disappearing within 3 to 4.5 years show promise as a pediatric interventional alternative to current strategies.

Original languageEnglish (US)
Article number101078
JournalMaterialia
Volume16
DOIs
StatePublished - May 2021
Externally publishedYes

Keywords

  • Degradation kinetics
  • Glass transition temperature
  • Poly(L-lactide)
  • Tensile strength

ASJC Scopus subject areas

  • Materials Science(all)

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