Abstract
Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.
Original language | English (US) |
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Article number | eade4687 |
Journal | Science Advances |
Volume | 9 |
Issue number | 8 |
DOIs | |
State | Published - Feb 2023 |
Funding
Acknowledgments Funding: Research reported in this publication was supported by the Center for Advanced RegenerativeEngineering(CARE)atNorthwesternUniversity..Elementalanalysiswas performedattheNorthwesternUniversityQuantitativeBio-elementImagingCentersupported byNASAAmesResearchCenterGrantNNA04CC36G.Imagingworkwasperformedatthe NorthwesternUniversityCenterforAdvancedMolecularImagingsupportedbyNCICCSGP30 CA060553awardedtotheRobertHLurieComprehensiveCancerCenter.Thisworkmadeuseof the NUFAB facility of Northwestern University’s NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern’s MRSEC program (NSFDMR-1720139).J.W .S. acknowledgessupportfromtheNationalInstituteofDiabetesand DigestiveandKidneyDiseases(grantno.R01DK131302),H.R.acknowledgessupportfromthe NationalResearchFoundationofKorea(NRF)grantfundedbytheKoreangovernment(MSIT) (nos.2022R1F1A1070994and2020M3H4A1A03084600).Z.X.acknowledgesthesupportfrom theNationalNaturalScienceFoundationofChina(grantno.12072057),DalianOutstanding YoungTalentsinScienceandT echnology (grantno.2021RJ06),LiaoNingRevitalizationTalents Program(grantno.XL YC2007196), andInternationalCooperationFundProjectofDBJI(grant no.ICR2110).Y .H. acknowledgessupportfromNSF(grantno.CMMI1635443).K.K. acknowledgessupportbytheNRFgrantfundedbytheKoreangovernment(MSIP;Ministryof Science,ICT&FuturePlanning;nos.2021R1F1A106387111,2022R1C1C1010555,and 2020R1A5A8018367).Authorcontributions:Conceptualization:J.W .S., H.R.,W .B., G.A.A.,and J.A.R.Methodology:J.W .S., H.R.,W .B., Z.X.,A.V .-G., andK.K..Investiga tion: J.W .S., H.R.,W .B., Z.X., A.V .-G., K.N.,R.A.,G.L.,Z.S.,J.K.,M.-K.L.,Y .L., M.K.,H.W ., Y .W ., H.-J.Y ., S.S.K.,J.S.,K.K.,W .L., X.C.,and Y .H. Fabrication:J.W .S., H.R.,W .B., A.V .-G., K.N.,G.L.,J.K.,M.-K.L.,Y .W ., H.-J.Y ., S.S.K.,W .L., andX.C. Visualization:J.W .S., H.R.,W .B., Z.X.,M.K.,andY .W .Supervision:G.A.A.andJ.A.R.Writing:All authors.Competinginterests:J.W .S., H.R.,G.A.A.,andJ.A.R.areinventorsonapatent applicationrelatedtothisworkfiledbyNorthwesternUniversity,Disc-ID-22-05-16-001,filed18 May2022.Theauthorsdeclarethattheyhavenoothercompetinginterests.Dataand materialsavailability:Alldataneededtoevaluatetheconclusionsinthepaperarepresentin thepaperand/ortheSupplementaryMaterials. Research reported in this publication was supported by the Center for Advanced Regenerative Engineering (CARE) at Northwestern University. . Elemental analysis was performed at the Northwestern University Quantitative Bio-element Imaging Center supported by NASA Ames Research Center Grant NNA04CC36G. Imaging work was performed at the Northwestern University Center for Advanced Molecular Imaging supported by NCI CCSG P30 CA060553 awarded to the Robert H Lurie Comprehensive Cancer Center. This work made use of the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern's MRSEC program (NSF DMR-1720139). J.W.S. acknowledges support from the National Institute of Diabetes and Digestive and Kidney Diseases (grant no. R01DK131302), H.R. acknowledges support from the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (nos. 2022R1F1A1070994 and 2020M3H4A1A03084600). Z.X. acknowledges the support from the National Natural Science Foundation of China (grant no. 12072057), Dalian Outstanding Young Talents in Science and Technology (grant no. 2021RJ06), LiaoNing Revitalization Talents Program (grant no. XLYC2007196), and International Cooperation Fund Project of DBJI (grant no. ICR2110). Y.H. acknowledges support from NSF (grant no. CMMI1635443). K.K. acknowledges support by the NRF grant funded by the Korean government (MSIP; Ministry of Science, ICT & Future Planning; nos. 2021R1F1A106387111, 2022R1C1C1010555, and 2020R1A5A8018367).
ASJC Scopus subject areas
- General