Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Joseph W. Song, Hanjun Ryu, Wubin Bai, Zhaoqian Xie, Abraham Vázquez-Guardado, Khizar Nandoliya, Raudel Avila, Geumbee Lee, Zhen Song, Jihye Kim, Min Kyu Lee, Yugang Liu, Mirae Kim, Huifeng Wang, Yixin Wu, Hong Joon Yoon, Sung Soo Kwak, Jaeho Shin, Kyeongha Kwon, Wei LuXuexian Chen, Yonggang Huang, Guillermo A. Ameer*, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Original languageEnglish (US)
Article numbereade4687
JournalScience Advances
Issue number8
StatePublished - Feb 2023

ASJC Scopus subject areas

  • General


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