Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Di Lu; Ying Yan; Raudel Avila; Irawati Kandela; Iwona Stepien; Min Ho Seo; Wubin Bai; Quansan Yang; Chenhang Li; Chad R. Haney; Emily A. Waters; Matthew R. MacEwan; Yonggang Huang; Wilson Z. Ray; John A. Rogers

doi:10.1002/adhm.202000942

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Di Lu, Ying Yan, Raudel Avila, Irawati Kandela, Iwona Stepien, Min Ho Seo, Wubin Bai, Quansan Yang, Chenhang Li, Chad R. Haney, Emily A. Waters, Matthew R. MacEwan, Yonggang Huang, Wilson Z. Ray, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response-related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. As an alternative, a battery-free, wireless implantable device is reported here, which is constructed entirely with bioresorbable materials for monitoring regional internal body temperatures over clinically relevant timeframes. Ultimately, these devices disappear completely in the body through natural processes. In vivo demonstrations indicate stable operation as subcutaneous and intracranial implants in rat models for up to 4 days. Potential applications include monitoring of healing cascades associated with surgical wounds, recovery processes following internal injuries, and the progression of thermal therapies for various conditions.

Original language	English (US)
Article number	2000942
Journal	Advanced Healthcare Materials
Volume	9
Issue number	16
DOIs	https://doi.org/10.1002/adhm.202000942
State	Published - Aug 1 2020

Funding

This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS‐1542205), the Materials Research Science and Engineering Center (NSF DMR‐1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey‐Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship. This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey-Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship.

Keywords

LC-resonance
biomedical implants
bioresorbable devices
regional body temperature
wireless sensors

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

Access to Document

10.1002/adhm.202000942

Cite this

Lu, D., Yan, Y., Avila, R., Kandela, I., Stepien, I., Seo, M. H., Bai, W., Yang, Q., Li, C., Haney, C. R., Waters, E. A., MacEwan, M. R., Huang, Y., Ray, W. Z., & Rogers, J. A. (2020). Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature. Advanced Healthcare Materials, 9(16), Article 2000942. https://doi.org/10.1002/adhm.202000942

@article{3bc11647c4354ec7b62ae248a55955b9,

title = "Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature",

abstract = "Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response-related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. As an alternative, a battery-free, wireless implantable device is reported here, which is constructed entirely with bioresorbable materials for monitoring regional internal body temperatures over clinically relevant timeframes. Ultimately, these devices disappear completely in the body through natural processes. In vivo demonstrations indicate stable operation as subcutaneous and intracranial implants in rat models for up to 4 days. Potential applications include monitoring of healing cascades associated with surgical wounds, recovery processes following internal injuries, and the progression of thermal therapies for various conditions.",

keywords = "LC-resonance, biomedical implants, bioresorbable devices, regional body temperature, wireless sensors",

author = "Di Lu and Ying Yan and Raudel Avila and Irawati Kandela and Iwona Stepien and Seo, {Min Ho} and Wubin Bai and Quansan Yang and Chenhang Li and Haney, {Chad R.} and Waters, {Emily A.} and MacEwan, {Matthew R.} and Yonggang Huang and Ray, {Wilson Z.} and Rogers, {John A.}",

note = "Funding Information: This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS‐1542205), the Materials Research Science and Engineering Center (NSF DMR‐1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey‐Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship. Funding Information: This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey-Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship. Publisher Copyright: {\textcopyright} 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2020",

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day = "1",

doi = "10.1002/adhm.202000942",

language = "English (US)",

volume = "9",

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T1 - Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

AU - Lu, Di

AU - Yan, Ying

AU - Avila, Raudel

AU - Kandela, Irawati

AU - Stepien, Iwona

AU - Seo, Min Ho

AU - Bai, Wubin

AU - Yang, Quansan

AU - Li, Chenhang

AU - Haney, Chad R.

AU - Waters, Emily A.

AU - MacEwan, Matthew R.

AU - Huang, Yonggang

AU - Ray, Wilson Z.

AU - Rogers, John A.

N1 - Funding Information: This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS‐1542205), the Materials Research Science and Engineering Center (NSF DMR‐1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey‐Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship. Funding Information: This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB) of Northwestern University's NUANCE Center, which received support from Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1720139) at the Materials Research Center, the International Institute for Nanotechnology (IIN), the Keck Foundation, the State of Illinois through the IIN, Northwestern University, and the Querrey-Simpson Institute for Bioelectronics. The Center for Developmental Therapeutics was supported by Cancer Center Support under Grant No. P30 CA060553 from the National Cancer Institute, awarded to the Robert H. Lurie Comprehensive Cancer Center. R.A. acknowledges support from the National Science Foundation Graduate Research Fellowship (NSF Grant No. 1842165) and Ford Foundation Predoctoral Fellowship. Publisher Copyright: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response-related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. As an alternative, a battery-free, wireless implantable device is reported here, which is constructed entirely with bioresorbable materials for monitoring regional internal body temperatures over clinically relevant timeframes. Ultimately, these devices disappear completely in the body through natural processes. In vivo demonstrations indicate stable operation as subcutaneous and intracranial implants in rat models for up to 4 days. Potential applications include monitoring of healing cascades associated with surgical wounds, recovery processes following internal injuries, and the progression of thermal therapies for various conditions.

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ER -

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Abstract

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Keywords

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