Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage

Shuo Li; Di Lu; Shupeng Li; Jiaqi Liu; Yameng Xu; Ying Yan; Jorge Zárate Rodriguez; Hedan Bai; Raudel Avila; Shuming Kang; Xinchen Ni; Haiwen Luan; Hexia Guo; Wubin Bai; Changsheng Wu; Xuhao Zhou; Ziying Hu; Mitchell A. Pet; Chet W. Hammill; Matthew R. MacEwan; Wilson Z. Ray; Yonggang Huang; John A. Rogers

doi:10.1126/sciadv.adj0268

Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage

Shuo Li, Di Lu^*, Shupeng Li, Jiaqi Liu, Yameng Xu, Ying Yan, Jorge Zárate Rodriguez, Hedan Bai, Raudel Avila, Shuming Kang, Xinchen Ni, Haiwen Luan, Hexia Guo, Wubin Bai, Changsheng Wu, Xuhao Zhou, Ziying Hu, Mitchell A. Pet, Chet W. Hammill, Matthew R. MacEwanWilson Z. Ray, Yonggang Huang, John A. Rogers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time monitoring of pH with fast response time (within 1 hour) over a clinically relevant period (up to 7 days) and timely detection of simulated gastric leaks in animal models. These concepts have broad potential applications for temporary sensing of relevant biomarkers during critical risk periods following diverse types of surgeries.

Original language	English (US)
Article number	eadj0268
Journal	Science Advances
Volume	10
Issue number	16
DOIs	https://doi.org/10.1126/sciadv.adj0268
State	Published - 2024

Funding

We acknowledge the Querrey Simpson Institute for Bioelectronics at Northwestern University for support of this research. D.L. acknowledges funding support from University of Science and Technology of China (KY2100000127 and KY2100000146). Shup. L. acknowledges support from the Ryan Fellowship and the International Institute for Nanotechnology (IIN) at Northwestern University. M.A.P. and M.R.M. acknowledge funding supporting from the Leadership in Entrepreneurial Acceleration Program (LEAP) at Washington University in St. Louis. Y.Y., C.W.H., and M.R.M. acknowledge funding supporting from the Emerson Collective Cancer Research Fund. Part of this work made use of the EPIC facility of Northwestern University\u2019s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633), the IIN, and Northwestern\u2019s Materials Research Science and Engineering Center (MRSEC) program (NSF DMR-1720139). We thank E. Rytkin for helpful discussions.

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Li, S., Lu, D., Li, S., Liu, J., Xu, Y., Yan, Y., Rodriguez, J. Z., Bai, H., Avila, R., Kang, S., Ni, X., Luan, H., Guo, H., Bai, W., Wu, C., Zhou, X., Hu, Z., Pet, M. A., Hammill, C. W., ... Rogers, J. A. (2024). Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage. Science Advances, 10(16), Article eadj0268. https://doi.org/10.1126/sciadv.adj0268

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title = "Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage",

abstract = "Continuous monitoring of biomarkers at locations adjacent to targeted internal organs can provide actionable information about postoperative status beyond conventional diagnostic methods. As an example, changes in pH in the intra-abdominal space after gastric surgeries can serve as direct indicators of potentially life-threatening leakage events, in contrast to symptomatic reactions that may delay treatment. Here, we report a bioresorbable, wireless, passive sensor that addresses this clinical need, designed to locally monitor pH for early detection of gastric leakage. A pH-responsive hydrogel serves as a transducer that couples to a mechanically optimized inductor-capacitor circuit for wireless readout. This platform enables real-time monitoring of pH with fast response time (within 1 hour) over a clinically relevant period (up to 7 days) and timely detection of simulated gastric leaks in animal models. These concepts have broad potential applications for temporary sensing of relevant biomarkers during critical risk periods following diverse types of surgeries.",

author = "Shuo Li and Di Lu and Shupeng Li and Jiaqi Liu and Yameng Xu and Ying Yan and Rodriguez, {Jorge Z{\'a}rate} and Hedan Bai and Raudel Avila and Shuming Kang and Xinchen Ni and Haiwen Luan and Hexia Guo and Wubin Bai and Changsheng Wu and Xuhao Zhou and Ziying Hu and Pet, {Mitchell A.} and Hammill, {Chet W.} and MacEwan, {Matthew R.} and Ray, {Wilson Z.} and Yonggang Huang and Rogers, {John A.}",

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Li, S, Lu, D, Li, S, Liu, J, Xu, Y, Yan, Y, Rodriguez, JZ, Bai, H, Avila, R, Kang, S, Ni, X, Luan, H, Guo, H, Bai, W, Wu, C, Zhou, X, Hu, Z, Pet, MA, Hammill, CW, MacEwan, MR, Ray, WZ, Huang, Y & Rogers, JA 2024, 'Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage', Science Advances, vol. 10, no. 16, eadj0268. https://doi.org/10.1126/sciadv.adj0268

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AU - Luan, Haiwen

AU - Guo, Hexia

AU - Bai, Wubin

AU - Wu, Changsheng

AU - Zhou, Xuhao

AU - Hu, Ziying

AU - Pet, Mitchell A.

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AU - Huang, Yonggang

AU - Rogers, John A.

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Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage

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