Biosynthetic polymers as functional materials

Andrea S. Carlini; Lisa Adamiak; Nathan C. Gianneschi

doi:10.1021/acs.macromol.6b00439

Biosynthetic polymers as functional materials

Andrea S. Carlini, Lisa Adamiak, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers.

Original language	English (US)
Pages (from-to)	4379-4394
Number of pages	16
Journal	Macromolecules
Volume	49
Issue number	12
DOIs	https://doi.org/10.1021/acs.macromol.6b00439
State	Published - Jun 28 2016

Funding

We acknowledge generous support from the AFOSR through a PECASE (FA9550-11-1-0105) and a BRI (FA9550-12-1-0414). We also acknowledge support from the NIH through a Director's New Innovator Award (1DP2OD008724), through the NIBIB (1R01EB011633), and for a Transformative Award (NHLBI R01HL117326). Further support comes from the ARO (W911NF-14-1-0169 and a MURI: W911NF-15-1-0568). A.S.C. thanks the NSF for a Graduate Research Fellowship (DGE-1144086).

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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Biosynthetic polymers as functional materials

Abstract

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ASJC Scopus subject areas

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