TY - JOUR
T1 - Biotinidase
T2 - Its role in biotinidase deficiency and biotin metabolism
AU - Wolf, Barry
N1 - Funding Information:
This paper was presented at the “International Symposium: Vitamins as Regulators of Genetic Expression: Biotin as a Model,” NAFTA Satellite Meeting to the XXV National Congress of Biochemistry, held December 3–4, 2004, in Ixtapa, Zihuatanejo, Mexico. This meeting was sponsored by Sociedad Mexicana de Bioquimica A.C.; Programa de Doctorado en Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico; Laboratorios Roche-Syntex, Mexico; and Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico.
Funding Information:
This work was supported in part by The Safra Research Fund.
PY - 2005/7
Y1 - 2005/7
N2 - Renewed interest in biotinidase, the enzyme responsible for recycling the vitamin biotin, initially came from the discovery of biotinidase deficiency in 1982. Since then, the elucidation of other activities of the enzyme, alternative splicing of the biotinidase gene and differential subcellular localization of the enzyme have prompted speculation and investigations of its other possible functions. The results of these studies have implicated biotinidase in aspects of biotin metabolism, specifically the biotinylation of various proteins, such as histones. Biotinidase may have an important regulatory role(s) in chromatin/DNA function.
AB - Renewed interest in biotinidase, the enzyme responsible for recycling the vitamin biotin, initially came from the discovery of biotinidase deficiency in 1982. Since then, the elucidation of other activities of the enzyme, alternative splicing of the biotinidase gene and differential subcellular localization of the enzyme have prompted speculation and investigations of its other possible functions. The results of these studies have implicated biotinidase in aspects of biotin metabolism, specifically the biotinylation of various proteins, such as histones. Biotinidase may have an important regulatory role(s) in chromatin/DNA function.
KW - Alternative splicing
KW - Biotin
KW - Biotinidase
KW - Biotinidase deficiency
KW - Biotinylation
KW - Subcellular localization
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U2 - 10.1016/j.jnutbio.2005.03.024
DO - 10.1016/j.jnutbio.2005.03.024
M3 - Article
C2 - 15992688
AN - SCOPUS:21344432793
VL - 16
SP - 441
EP - 445
JO - Nutrition Reports International
JF - Nutrition Reports International
SN - 0955-2863
IS - 7
ER -
