Biotranport and biocompatibility of nanoporous biocapsules

Lara Leoni, Tejal A. Desai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

This study investigates whether nanoporous micromachined biocapsules, with uniform membrane pore sizes of 24.5 nm, can be used to encapsulate insulin secreting cells in vitro. This approach to cell encapsulation is based on microfabrication technology whereby immunoisolation membranes are bulk and surface micromachined to present uniform and wellcontrolled pore sizes as small as 10 nanometers, tailored surface chemistries, and precise microarchitectures. This study evaluates the behavior of insulinoma cells with micromachined membranes, the effect of matrix configurations within the biocapsule on cell behavior, as well as insulin and glucose transport through the biocapsule membranes.

Original languageEnglish (US)
Title of host publication1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
EditorsAndre Dittmar, David Beebe
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages113-117
Number of pages5
ISBN (Electronic)0780366034, 9780780366039
DOIs
StatePublished - 2000
Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
Duration: Oct 12 2000Oct 14 2000

Publication series

Name1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Conference

Conference1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
Country/TerritoryFrance
CityLyon
Period10/12/0010/14/00

ASJC Scopus subject areas

  • General Engineering

Fingerprint

Dive into the research topics of 'Biotranport and biocompatibility of nanoporous biocapsules'. Together they form a unique fingerprint.

Cite this