TY - JOUR
T1 - Birth weight and subsequent risk of cancer
AU - Spracklen, Cassandra N.
AU - Wallace, Robert B.
AU - Sealy-Jefferson, Shawnita
AU - Robinson, Jennifer G.
AU - Freudenheim, Jo L.
AU - Wellons, Melissa F.
AU - Saftlas, Audrey F.
AU - Snetselaar, Linda G.
AU - Manson, Jo Ann E.
AU - Hou, Lifang
AU - Qi, Lihong
AU - Chlebowski, Rowan T.
AU - Ryckman, Kelli K.
N1 - Funding Information:
We thank the WHI investigators and staff for their dedication and the study participants for making the program possible. The WHI program is funded by the National Heart, Lung, and Blood Institute , National Institutes of Health , U.S. Department of Health and Human Services through contracts HHSN268201100046C , HHSN268201100001C , HHSN268201100002C , HHSN268201100003C , HHSN268201100004C , and HHSN271201100004C .
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background: We aimed to determine the association between self-reported birth weight and incident cancer in the Women's Health Initiative Observational Study cohort, a large multiethnic cohort of postmenopausal women. Methods: 65,850 women reported their birth weight by category (<6. lbs, 6-7. lbs 15. oz, 8-9. lbs 15. oz, and ≥10. lbs). All self-reported, incident cancers were adjudicated by study staff. We used Cox proportional hazards regression to estimate crude and adjusted hazard ratios (aHR) for associations between birth weight and: (1) all cancer sites combined, (2) gynecologic cancers, and (3) several site-specific cancer sites. Results: After adjustments, birth weight was positively associated with the risk of lung cancer (. p=. 0.01), and colon cancer (. p=. 0.04). An inverse trend was observed between birth weight and risk for leukemia (. p=. 0.04). A significant trend was not observed with breast cancer risk (. p=. 0.67); however, women born weighing ≥10. lbs were less likely to develop breast cancer compared to women born between 6. lbs-7. lbs 15. oz (aHR 0.77, 95% CI 0.63, 0.94). Conclusion: Birth weight category appears to be significantly associated with the risk of any postmenopausal incident cancer, though the direction of the association varies by cancer type.
AB - Background: We aimed to determine the association between self-reported birth weight and incident cancer in the Women's Health Initiative Observational Study cohort, a large multiethnic cohort of postmenopausal women. Methods: 65,850 women reported their birth weight by category (<6. lbs, 6-7. lbs 15. oz, 8-9. lbs 15. oz, and ≥10. lbs). All self-reported, incident cancers were adjudicated by study staff. We used Cox proportional hazards regression to estimate crude and adjusted hazard ratios (aHR) for associations between birth weight and: (1) all cancer sites combined, (2) gynecologic cancers, and (3) several site-specific cancer sites. Results: After adjustments, birth weight was positively associated with the risk of lung cancer (. p=. 0.01), and colon cancer (. p=. 0.04). An inverse trend was observed between birth weight and risk for leukemia (. p=. 0.04). A significant trend was not observed with breast cancer risk (. p=. 0.67); however, women born weighing ≥10. lbs were less likely to develop breast cancer compared to women born between 6. lbs-7. lbs 15. oz (aHR 0.77, 95% CI 0.63, 0.94). Conclusion: Birth weight category appears to be significantly associated with the risk of any postmenopausal incident cancer, though the direction of the association varies by cancer type.
KW - Birth weight
KW - Breast neoplasms
KW - Colorectal neoplasms
KW - Endometrial neoplasms
KW - Leukemia
KW - Lung neoplasms
KW - Neoplasms
KW - Ovarian neoplasms
UR - http://www.scopus.com/inward/record.url?scp=84908092210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908092210&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2014.07.004
DO - 10.1016/j.canep.2014.07.004
M3 - Article
C2 - 25096278
AN - SCOPUS:84908092210
SN - 1877-7821
VL - 38
SP - 538
EP - 543
JO - Cancer Epidemiology
JF - Cancer Epidemiology
IS - 5
ER -
