TY - JOUR
T1 - Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy
AU - Sharma, Bhavya
AU - Bugga, Pradeep
AU - Madison, Lindsey R.
AU - Henry, Anne Isabelle
AU - Blaber, Martin G.
AU - Greeneltch, Nathan G.
AU - Chiang, Naihao
AU - Mrksich, Milan
AU - Schatz, George C.
AU - Van Duyne, Richard P.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10/26
Y1 - 2016/10/26
N2 - This paper demonstrates the direct sensing of glucose at physiologically relevant concentrations with surface-enhanced Raman spectroscopy (SERS) on gold film-over-nanosphere (AuFON) substrates functionalized with bisboronic acid receptors. The combination of selectivity in the bisboronic acid receptor and spectral resolution in the SERS data allow the sensors to resolve glucose in high backgrounds of fructose and, in combination with multivariate statistical analysis, detect glucose accurately in the 1-10 mM range. Computational modeling supports assignments of the normal modes and vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose. These results are promising for the use of bisboronic acids as receptors in SERS-based in vivo glucose monitoring sensors.
AB - This paper demonstrates the direct sensing of glucose at physiologically relevant concentrations with surface-enhanced Raman spectroscopy (SERS) on gold film-over-nanosphere (AuFON) substrates functionalized with bisboronic acid receptors. The combination of selectivity in the bisboronic acid receptor and spectral resolution in the SERS data allow the sensors to resolve glucose in high backgrounds of fructose and, in combination with multivariate statistical analysis, detect glucose accurately in the 1-10 mM range. Computational modeling supports assignments of the normal modes and vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose. These results are promising for the use of bisboronic acids as receptors in SERS-based in vivo glucose monitoring sensors.
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U2 - 10.1021/jacs.6b07331
DO - 10.1021/jacs.6b07331
M3 - Article
C2 - 27668444
AN - SCOPUS:84992745444
SN - 0002-7863
VL - 138
SP - 13952
EP - 13959
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 42
ER -