@article{5808f08ddda44f378a5bc92ead60a446,
title = "BK virus capsid antibodies are associated with protection against subsequent development of PML in HIV-infected patients",
abstract = "Progressive multifocal leukoencephalopathy (PML) is caused by JC polyomavirus (JCPyV). Because a reciprocal relationship has been described between antibody levels to JCPyV and BK polyomavirus (BKPyV), we performed a nested case control study with pre-diagnostic serum samples from HIV infected subjects to examine the relationship between BKPyV capsid antibodies and the risk of PML. Serum samples collected 0.5-2 years before PML diagnosis from 25 cases (66 samples) and 80 matched controls (204 samples) were tested in ELISA for JCPyV, BKPyV type 1 and type 4 capsid antibodies. High levels of BKPyV 1 and 4 antibodies were associated with a lower risk of PML (BKPyV 1 OR, 0.56, 95% CI, 0.35-0.89; BKPyV 4 OR, 0.40, 95% CI, 0.24-0.0.67). Our study demonstrates that antibodies to BKPyV capsids are an immunological marker of protection against development of PML. Further studies are needed to define the mechanism.",
keywords = "BK polyomavirus, Cohort study, Human immunodeficiency virus, JC polyomavirus, Progressive multifocal leukoencephalopathy, Viral serology",
author = "Francesca Rossi and Xiuhong Li and Lisa Jacobson and Levine, {Andrew J.} and Yue Chen and Palella, {Frank J.} and Joseph Margolick and Raphael Viscidi",
note = "Funding Information: We thank Barbara Silver for technical assistance with ELISA assays. This study was sponsored in part by a grant from the PML Consortium (RPV) [Grant no. 114244 ]. Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (Principal Investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson), Howard Brown Health Center, Feinberg School of Medicine, Northwestern University, and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky), University of California, Los Angeles (Roger Detels), and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases , with additional supplemental funding from the National Cancer Institute [Grant nos. UO1-AI-35042 , 5-MO1-RR-00052 (GCRC) , UO1-AI-35043 , UO1-AI-35039 , UO1-AI-35040 , and UO1-AI-35041 ]. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = nov,
day = "1",
doi = "10.1016/j.virol.2015.08.022",
language = "English (US)",
volume = "485",
pages = "467--472",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
}
