Abstract
Objective: To use a large current prospective cohort of infants <29 weeks to compare bronchopulmonary dysplasia (BPD) rates in black and white infants. Study design: The Prematurity and Respiratory Outcome Program (PROP) enrolled 835 infants born in 2011-2013 at <29 weeks of gestation; 728 black or white infants survived to 36 weeks postmenstrual age (PMA). Logistic regression was used to compare BPD outcomes (defined as supplemental oxygen requirement at 36 weeks PMA) between the races, adjusted for gestational age (GA), antenatal steroid use, intubation at birth, and surfactant use at birth. Results: Of 707 black or white infants with available BPD outcomes, BPD was lower in black infants (38% vs 45%), even though they were of significantly lower GA. At every GA, BPD was more common in white infants. The aOR for BPD was 0.60 (95% CI, 0.42-0.85; P =.004) for black infants compared with white infants after adjusting for GA. Despite the lower rate of BPD, black infants had a higher rate of first-year post-prematurity respiratory disease (black, 79%; white, 63%). Conclusions: In this large cohort of recently born preterm infants at <29 weeks GA, compared with white infants, black infants had a lower risk of BPD but an increased risk of persistent respiratory morbidity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 130-135.e2 |
| Journal | journal of pediatrics |
| Volume | 207 |
| DOIs | |
| State | Published - Apr 2019 |
Funding
Supported by National Institutes of Health Grants U01 HL101794 (University of Pennsylvania), U01 HL101456 (Vanderbilt University), U01 HL101798 (University of California San Francisco), U01 HL101813 (University of Rochester and University at Buffalo), U01 HL101465 (Washington University), U01 HL101800 (Cincinnati Children's Hospital Medical Center), and 5R01 HL105702 (Indiana University and Duke University). The authors declare no conflicts of interest. Supported by National Institutes of Health Grants U01 HL101794 (University of Pennsylvania) U01 HL101456 (Vanderbilt University) U01 HL101798 (University of California San Francisco) U01 HL101813 (University of Rochester and University at Buffalo) U01 HL101465 (Washington University) U01 HL101800 (Cincinnati Children's Hospital Medical Center), and 5R01 HL105702 (Indiana University and Duke University). The authors declare no conflicts of interest. We would like to acknowledge all research staff by site: Cincinnati Children's Hospital Medical Center site: Barbara Alexander, RN, Tari Gratton, PA, Cathy Grigsby, BSN, CCRC, Beth Koch, BHS, RRT, RPFT, Kelly Thornton BS; Washington University School of Medicine site: Pamela Bates, CRT, RPFT, RPSGT, Claudia Cleveland, RRT, Julie Hoffmann, RN, Laura Linneman, RN, Jayne Sicard-Su, RN, Gina Simpson, RRT, CPFT; University of California San Francisco site: Jeanette M. Asselin, MS, RRT-NPS1, Samantha Balan, Katrina Burson, RN, BSN4, Cheryl Chapin, Erna Josiah-Davis, RN, NP2, Carmen Garcia, RN, CCRP4, Hart Horneman, Rick Hinojosa, BSRT, RRT, CPFT-NPS3, Christopher Johnson, MBA, RRT3, Susan Kelley, RRT, Karin L. Knowles, M. Layne Lillie, RN, BSN3, Karen Martin, RN3, Sarah Martin, RN, BSN; Julie Arldt-McAlister, RN, BSN3, Georgia E. McDavid, RN3, Lori Pacello, RCP1, Shawna Rodgers, RN, BSN3, Daniel K. Sperry, RN3 1Children's Hospital and Research Center Oakland, Oakland, CA; 2Alta Bates Summit Medical Center, Berkeley, CA; 3University of Texas Health Science Center Houston, Houston, TX; Vanderbilt University Medical Center site: Amy B. Beller, BSN, Mark O. Hunt, Theresa J. Rogers, RN, Odessa L. Settles, RN, MSN, CM, Steven Steele, RN, Sharon Wadley, BSN, RN, CLS1; 1Jackson-Madison County General Hospital, Jackson, TN; University of Rochester Medical Center/University at Buffalo, NY: Shannon Castiglione, RN, Aimee Horan, LPN, Deanna Maffet, RN, Jane O'Donnell, PNP, Michael Sacilowski, MAT, Tanya Scalise, RN, BSN, Elizabeth Werner, MPH, Jason Zayac, BS, Heidie Huyck, BS, Valerie Lunger, MS, Kim Bordeaux, RRT, Pam Brown, RRT, Julia Epping, AAS, RT, Lisa Flattery-Walsh, RRT, Donna Germuga, RRT, CPFT, Nancy Jenks, RN, Mary Platt, RN, Eileen Popplewell, RRT, Sandra Prentice, CRT; Duke University site: Kim Ciccio, RN; Indiana University site: Charles Clem, RRT, Susan Gunn, NNP, CCRC, Lauren Jewett, RN, CCRC; University of Pennsylvania, Perelman School of Medicine, DCC site: Maria Blanco, BS, Denise Cifelli, MS, Sara DeMauro, MD, Melissa Fernando, MPH, Ann Tierney, BA, MS; Steering Committee Chair: Lynn M. Taussig, MD, University of Denver; National Heart, Lung, and Blood Institute Program Officer: Carol J. Blaisdell, MD Supported by National Institutes of Health Grants U01 HL101794 (University of Pennsylvania) U01 HL101456 (Vanderbilt University) U01 HL101798 (University of California San Francisco) U01 HL101813 (University of Rochester and University at Buffalo) U01 HL101465 (Washington University) U01 HL101800 (Cincinnati Children's Hospital Medical Center), and 5R01 HL105702 (Indiana University and Duke University). The authors declare no conflicts of interest. Supported by National Institutes of Health Grants U01 HL101794 ( University of Pennsylvania ), U01 HL101456 ( Vanderbilt University ), U01 HL101798 ( University of California San Francisco ), U01 HL101813 ( University of Rochester and University at Buffalo ), U01 HL101465 ( Washington University ), U01 HL101800 ( Cincinnati Children's Hospital Medical Center ), and 5R01 HL105702 ( Indiana University and Duke University ). The authors declare no conflicts of interest. Supported by National Institutes of Health Grants U01 HL101794 (University of Pennsylvania), U01 HL101456 (Vanderbilt University), U01 HL101798 (University of California San Francisco), U01 HL101813 (University of Rochester and University at Buffalo), U01 HL101465 (Washington University), U01 HL101800 (Cincinnati Children's Hospital Medical Center), and 5R01 HL105702 (Indiana University and Duke University). The authors declare no conflicts of interest.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health