Bladder tissue engineering through nanotechnology

Daniel A. Harrington, Arun K. Sharma, Bradley A. Erickson, Earl Y. Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The field of tissue engineering has developed in phases: initially researchers searched for "inert" biomaterials to act solely as replacement structures in the body. Then, they explored biodegradable scaffolds - both naturally derived and synthetic - for the temporary support of growing tissues. Now, a third phase of tissue engineering has developed, through the subcategory of "regenerative medicine." This renewed focus toward control over tissue morphology and cell phenotype requires proportional advances in scaffold design. Discoveries in nanotechnology have driven both our understanding of cell - substrate interactions, and our ability to influence them. By operating at the size regime of proteins themselves, nanotechnology gives us the opportunity to directly speak the language of cells, through reliable, repeatable creation of nanoscale features. Understanding the synthesis of nanoscale materials, via "top-down" and "bottom-up" strategies, allows researchers to assess the capabilities and limits inherent in both techniques. Urology research as a whole, and bladder regeneration in particular, are well-positioned to benefit from such advances, since our present technology has yet to reach the end goal of functional bladder restoration. In this article, we discuss the current applications of nanoscale materials to bladder tissue engineering, and encourage researchers to explore these interdisciplinary technologies now, or risk playing catch-up in the future.

Original languageEnglish (US)
Pages (from-to)315-322
Number of pages8
JournalWorld journal of urology
Volume26
Issue number4
DOIs
StatePublished - 2008

Keywords

  • Biomaterial
  • Bladder
  • Bottom-up
  • Nanotechnology
  • Regenerative medicine
  • Scaffold
  • Self-assembly
  • Stem cell
  • Supramolecular
  • Tissue engineering
  • Top-down

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Bladder tissue engineering through nanotechnology'. Together they form a unique fingerprint.

Cite this