Block Copolymer Amphiphile Phase Diagrams by High-Throughput Transmission Electron Microscopy

Mollie A. Touve, Daniel B. Wright, Chen Mu, Hao Sun, Chiwoo Park, Nathan Gianneschi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In this paper, we show the rapid generation of phase diagrams for block copolymer amphiphiles. We demonstrate the high-Throughput approach for two separate types of amphiphilic block copolymers: One type consisting of poly(ethylene glycol)-b-poly(2-hydroxypropyl methacrylate) and the other consisting of poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-hydroxypropyl methacrylate), where each amphiphilic block copolymer was prepared by systematically varying the degree of polymerization of the hydrophobic block. These were each synthesized in 96-well plates using polymerization-induced self-Assembly to rapidly generate a range of morphologies in aqueous solution. In this manner, 45 different assembled polymer samples were prepared at a time. These samples were sampled by automated picoliter volume liquid handling (piezoelectric robotic dispenser) and analyzed by automated transmission electron microscopy and automated image analysis to rapidly generate phase diagrams.

Original languageEnglish (US)
Pages (from-to)5529-5537
Number of pages9
JournalMacromolecules
Volume52
Issue number15
DOIs
StatePublished - Aug 13 2019

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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