Blockade of specific NOTCH ligands: A new promising approach in cancer therapy

Anaïs Briot; M. Luisa Iruela-Arispe

doi:10.1158/2159-8290.CD-14-1501

Blockade of specific NOTCH ligands: A new promising approach in cancer therapy

Anaïs Briot, M. Luisa Iruela-Arispe^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.

Original language	English (US)
Pages (from-to)	112-114
Number of pages	3
Journal	Cancer discovery
Volume	5
Issue number	2
DOIs	https://doi.org/10.1158/2159-8290.CD-14-1501
State	Published - Feb 1 2015

ASJC Scopus subject areas

Oncology

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abstract = "The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis.",

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