Blocking versus cytotoxic antibody in HL-A- and mixed lymphocyte culture-identical and nonidentical human renal transplant recipients

Joshua Miller, Judith Lifton, Faye Rood, Brack G. Hattler

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Blocking antibody directed against donor responding cells has been found to develop in HL-A-mixed lymphocyte culture-identical donor-recipient combinations after renal transplantation in which splenectomy was not perfortned. Cytotoxic antibody associated with rejection episodes and detected only by the discriminatory mixed lymphocyte culture developed in other HL-A-mixed lymphocyte culture-identical combinations as well. It disappeared as blocking antibody appeared and the post-transplant course became uneventful. In addition, both cytotoxic and blocking activity were shown to develop and coexist in a patient who received two successive renal transplants: Cytotoxic against donor 1 (kidney rejected), and blocking against donor 2 (kidney accepted). These findings are taken to be strong evidence in favor of qualitatively demonstrable separate antibody molecules dealing with two separate functions, i.e., cytotoxicity versus enhancement or immunoregulation.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalTransplantation
Volume20
Issue number1
DOIs
StatePublished - Jul 1975

ASJC Scopus subject areas

  • Transplantation

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