TY - JOUR
T1 - Blood and affective markers of stress in Elite Airmen during a preparatory training course
T2 - A pilot study
AU - Jenz, S. T.
AU - Goodyear, C. D.
AU - TSgt Graves, P. R.
AU - Goldstein, S.
AU - Shia, M. R.
AU - Redei, E. E.
N1 - Funding Information:
This material is based on research sponsored by the Air Force Research laboratory under agreement number is FA8650-15-2-5518. The manuscript has been approved for public release (Distribution A: Approved for public release, Cleared November 17, 2020; Unit Case#: AFRL-2020-0286, AFIMSC Case#: MSC-2020-0260). The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of Air Force Research Laboratory or the U.S. Government.
Funding Information:
This material is based on research sponsored by the Air Force Research laboratory under agreement number is FA8650-15-2-5518 . The manuscript has been approved for public release (Distribution A: Approved for public release, Cleared November 17, 2020; Unit Case#: AFRL-2020-0286, AFIMSC Case#: MSC-2020-0260). The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of Air Force Research Laboratory or the U.S. Government.
Publisher Copyright:
© 2021 The Authors
PY - 2021/5
Y1 - 2021/5
N2 - In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats’ blood and brain, and overlapping significant differentially expressed genes were selected. Serum levels of human orthologues of these proteins, in lieu of blood RNA, in addition to classic stress and general clinical markers, were measured in 33 Battlefield Airmen undergoing a 52 day long preparatory training course before their course of initial entry (COIE). Blood samples and factors of affective state, negative valence “Threat” and positive valence “Challenge”, were obtained five times across different days of training which included either routine physical exercise or prolonged and intense physical and mental training. During training, levels of chloride (Cl), dehydroepiandrosterone-sulfate (DHEA-S), creatinine kinase (CK), and total carbon dioxide (TCO2) differed between airmen who subsequently graduated from their COIE and those who did not. Time dependent changes of serum TCO2 and neuropeptide Y (NPY), as well as the affective factor Challenge differed by future graduation status throughout the training. Serum levels of parvin beta (PARVB) correlated with the affective factor Threat, while those of NPY, testosterone, coactosin like F-actin binding protein 1 (COTL1) and C-reactive protein (CRP) correlated with factor Challenge during the extended, intensive periods of training, consistently. These pilot data suggest that the identified panel of blood markers can measure stress responsiveness, which has the potential to advance individualized stress-management strategies.
AB - In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats’ blood and brain, and overlapping significant differentially expressed genes were selected. Serum levels of human orthologues of these proteins, in lieu of blood RNA, in addition to classic stress and general clinical markers, were measured in 33 Battlefield Airmen undergoing a 52 day long preparatory training course before their course of initial entry (COIE). Blood samples and factors of affective state, negative valence “Threat” and positive valence “Challenge”, were obtained five times across different days of training which included either routine physical exercise or prolonged and intense physical and mental training. During training, levels of chloride (Cl), dehydroepiandrosterone-sulfate (DHEA-S), creatinine kinase (CK), and total carbon dioxide (TCO2) differed between airmen who subsequently graduated from their COIE and those who did not. Time dependent changes of serum TCO2 and neuropeptide Y (NPY), as well as the affective factor Challenge differed by future graduation status throughout the training. Serum levels of parvin beta (PARVB) correlated with the affective factor Threat, while those of NPY, testosterone, coactosin like F-actin binding protein 1 (COTL1) and C-reactive protein (CRP) correlated with factor Challenge during the extended, intensive periods of training, consistently. These pilot data suggest that the identified panel of blood markers can measure stress responsiveness, which has the potential to advance individualized stress-management strategies.
KW - Affective measures
KW - Battlefield airmen
KW - Preparatory training
KW - Serum stress markers
KW - Stress-severity
UR - http://www.scopus.com/inward/record.url?scp=85104083539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104083539&partnerID=8YFLogxK
U2 - 10.1016/j.ynstr.2021.100323
DO - 10.1016/j.ynstr.2021.100323
M3 - Article
C2 - 33912629
AN - SCOPUS:85104083539
SN - 2352-2895
VL - 14
JO - Neurobiology of Stress
JF - Neurobiology of Stress
M1 - 100323
ER -