Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects

Maria T. Caserta; Daniel Caccioppo; Gregory D. Lapin; Ann Ragin; Dennis R. Groothuis

doi:10.1176/jnp.10.1.78

Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects

Maria T. Caserta^*, Daniel Caccioppo, Gregory D. Lapin, Ann Ragin, Dennis R. Groothuis

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A defective blood-brain barrier (BBB) has been postulated to be present in Alzheimer's disease (AD), which would allow circulating β-amyloid peptide to enter the brain. The authors tested this hypothesis by studying BBB function in 14 individuals with probable AD and 9 elderly control subjects. A computed tomographic method was used to measure blood-to-brain transport (K₁), tissue-to-blood efflux (k₂), tissue plasmia space (V(p)), and tissue extracellular space (V(e)) of meglumine iothalamate. Repeated-measures analysis of variance indicated no significant differences between the groups for any of the measures. The authors conclude that there is no generalized abnormality of the blood-brain barrier in AD.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	10
Issue number	1
DOIs	https://doi.org/10.1176/jnp.10.1.78
State	Published - Jan 1 1998

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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abstract = "A defective blood-brain barrier (BBB) has been postulated to be present in Alzheimer's disease (AD), which would allow circulating β-amyloid peptide to enter the brain. The authors tested this hypothesis by studying BBB function in 14 individuals with probable AD and 9 elderly control subjects. A computed tomographic method was used to measure blood-to-brain transport (K1), tissue-to-blood efflux (k2), tissue plasmia space (V(p)), and tissue extracellular space (V(e)) of meglumine iothalamate. Repeated-measures analysis of variance indicated no significant differences between the groups for any of the measures. The authors conclude that there is no generalized abnormality of the blood-brain barrier in AD.",

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AU - Caccioppo, Daniel

AU - Lapin, Gregory D.

AU - Ragin, Ann

AU - Groothuis, Dennis R.

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Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects

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