Blood-brain barrier integrity in Alzheimer's disease patients and elderly control subjects

Maria T. Caserta*, Daniel Caccioppo, Gregory D. Lapin, Ann Ragin, Dennis R. Groothuis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


A defective blood-brain barrier (BBB) has been postulated to be present in Alzheimer's disease (AD), which would allow circulating β-amyloid peptide to enter the brain. The authors tested this hypothesis by studying BBB function in 14 individuals with probable AD and 9 elderly control subjects. A computed tomographic method was used to measure blood-to-brain transport (K1), tissue-to-blood efflux (k2), tissue plasmia space (V(p)), and tissue extracellular space (V(e)) of meglumine iothalamate. Repeated-measures analysis of variance indicated no significant differences between the groups for any of the measures. The authors conclude that there is no generalized abnormality of the blood-brain barrier in AD.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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